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https://www.arca.fiocruz.br/handle/icict/14257
ASSESSMENT OF SPECKLE TRACKING STRAIN PREDICTIVE VALUE FOR MYOCARDIAL FIBROSIS IN SUBJECTS WITH CHAGAS DISEASE
Author
Affilliation
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil
Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
Background: One of the most challenging issues of chronic Chagas disease is to provide earlier detection of heart
involvement. Two-dimensional speckle tracking (2-D ST) echocardiography, a new imagingmodalitywith useful
applications in several cardiac diseases, has been validated for subjects with myocardial infarction against cardiac
magnetic resonance (CMR). Here we hypothesize that the longitudinal global strain (LGS) has an incremental
value to ejection fraction for predicting myocardial fibrosis in subjects with Chagas disease.
Methods: This observational study comprised 58 subjectswith Chagas disease, confirmed by two positive serologic
tests. All subjects underwent conventional Doppler echocardiogramplus speckle tracking strain, and cardiacmagnetic
resonance.
Results: The ROC curve analysis revealed that both LGS (area under the curve: 0.78, p=0.001) and ejection fraction
(area under the curve: 0.82, p b 0.001)were significant predictors ofmyocardial fibrosis. Regarding the percentage
of fibrosis, a high correlation was observed with both ejection fraction assessed by echocardiography (r =0.70,
p b 0.001) and LGS (r = 0.64, p b 0.001). However, when adjusted through multiple linear regression, the LGS
lost statistical significance as a predictor of myocardial fibrosis (p = 0.111).
Conclusions: LGS has no incremental value to conventional ejection fractionmeasurement in the prediction ofmyocardial
fibrosis in subjects with Chagas disease.
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