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ANTIBODY SIGNATURES REFLECT DIFFERENT DISEASE PATHOLOGIES IN SCHISTOSOMIASIS JAPONICA
Driguez, Patrick et al. | Data do documento: 2016
Autor(es)
Driguez, Patrick
Li, Yuesheng
Jangola, Soraya Torres Gaze
Pearson, Mark S.
Nakajima, Rie
Trieu, Angela
Doolan, Denise L.
Felgner, Philip L.
Hou, Xunya
Cardoso, Fernanda C.
Jasinskas, Algis
Gobert, Geoffrey N.
Loukas, Alex
McManus, Donald P.
Afiliação
QIMR Berghofer Medical Research Institute. Brisbane.
QIMR Berghofer Medical Research Institute. Brisbane/Hunan Institute of Parasitic Diseases. Yueyang, China.
James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Queensland Tropical Health Alliance Laboratory. Cairns/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Queensland Tropical Health Alliance Laboratory. Cairns
University of California.Irvine, CA, USA.
QIMR Berghofer Medical Research Institute. Brisbane.
QIMR Berghofer Medical Research Institute. Brisbane.
University of California.Irvine, CA, USA.
Hunan Institute of Parasitic Diseases.Yueyang, China.
QIMR Berghofer Medical Research Institute/University of Queensland. Brisbane Institute for Molecular Biosciences. St. Lucia, Australia.
University of California.Irvine, CA, USA.
QIMR Berghofer Medical Research Institute. Brisbane.
James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Queensland Tropical Health Alliance Laboratory. Cairns
QIMR Berghofer Medical Research Institute. Brisbane.
Resumo em Inglês
Infection with Schistosoma japonicum causes high levels of pathology that is predominantly determined by the cellular and humoral response of the host. However, the specific antibody response that arises during the development of disease is largely undescribed in Asian schistosomiasis-endemic populations. A schistosome protein microarray was used to compare the antibody profiles of subjects with acute infection, with early or advanced disease associated with severe pathology, with chronic infection, and subjects exposed but stool negative for S. japonicum eggs to the antibody profiles of nonexposed controls. Twenty-five immunodominant antigens were identified, including vaccine candidates, tetraspanin-related proteins, transporter molecules, and unannotated proteins. Additionally, individuals with severe pathology had a limited specific antibody response, suggesting that individuals with mild disease may use a broad and strong antibody response, particularly against surface-exposed proteins, to control pathology and/or infection. Our study has identified specific antigens that can discriminate between S. japonicum-exposed groups with different pathologies and may also allow the host to control disease pathology and provide resistance to parasite infection.
Palavras-chave em inglês
Schistosoma japonicum
antibody
human disease
immunology
protein microarray
schistosomiasis
 
Editor
University of Chicago Press
Referência
DRIGUEZ, Patrick et al. Antibody signatures reflect different disease pathologies in schistosomiasis japonica. J Infect Dis., vol. 213, n. 1, p. 122-130, 2016.
DOI
10.1093/infdis/jiv356
ISSN
0022-1899