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ANTITUMOUR ACTIVITY OF THE MICROENCAPSULATION OF ANNONA
Annonaceae
Óleos essenciais
Citotoxicidade
Anticorpos antitumor
Microencapsulação
Ratos
10.1111/bcpt.12488
Autor
Bomfim, Larissa Mendes
Menezes, Leociley Rocha Alencar
Rodrigues, Ana Carolina B. C
Dias, Rosane Borges
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Santana Neto, Albertino Freitas
Nascimento, Magaly Pinto
Campos, Adriana F
Silva, Lidercia Cavalcanti Ribeiro Cerqueira e
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
Menezes, Leociley Rocha Alencar
Rodrigues, Ana Carolina B. C
Dias, Rosane Borges
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Santana Neto, Albertino Freitas
Nascimento, Magaly Pinto
Campos, Adriana F
Silva, Lidercia Cavalcanti Ribeiro Cerqueira e
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
Afiliación
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Crist ovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Propedeutics. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil
Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil
Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Crist ovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Propedeutics. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil
Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil
Northeastern Center for Strategic Technologies. CETENE. Recife, PE, Brasil
Federal University of Bahia. Faculty of Pharmacy. Salvador, BA, Brasil
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Resumen en ingles
Annona vepretorum Mart. (Annonaceae), popularly known as ‘bruteira’, has nutritional and medicinal uses. This study
investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed
with b-cyclodextrin in a microencapsulation. The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus
and analysed using GC-MS and GC-FID. In vitro cytotoxicity of the essential oil and some of its major constituents in tumour
cell lines from different histotypes was evaluated using the alamar blue assay. Furthermore, the in vivo efficacy of essential oil
was demonstrated in mice inoculated with B16-F10 mouse melanoma. The essential oil included bicyclogermacrene (35.71%),
spathulenol (18.89%), (E)-b-ocimene (12.46%), a-phellandrene (8.08%), o-cymene (6.24%), germacrene D (3.27%) and a-pinene
(2.18%) as major constituents. The essential oil and spathulenol exhibited promising cytotoxicity. In vivo tumour growth was
inhibited by the treatment with the essential oil (inhibition of 34.46%). Importantly, microencapsulation of the essential oil
increased in vivo tumour growth inhibition (inhibition of 62.66%).
Palabras clave en portugues
AnnonaAnnonaceae
Óleos essenciais
Citotoxicidade
Anticorpos antitumor
Microencapsulação
Ratos
Editor
Wiley
Referencia
BOMFIM, L. M. et al. Antitumour Activity of the Microencapsulation of Annona. Basic & Clinical Pharmacology Toxicology, v. 118, n. 3, p. 208-213, 2016.ISSN
1742-784310.1111/bcpt.12488
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