Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/1261
EPIDEMIOLOGICAL AND GENETIC ANALYSES OF HEPATITIS C VIRUS TRANSMISSION AMONG YOUNG/SHORT- AND LONG-TERM INJECTING DRUG USERS FROM RIO DE JANEIRO, BRAZIL
Substance abuse
Hepatitis C virus
HCV epidemiology
HCV subtypes
Phylogenetic analysis
Autor(es)
Afiliação
National Reference Laboratory for Viral Hepatitis & National Reference Laboratory for Influenza and Exanthematic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Oswaldo Cruz Foundation. Department of Health Information. Rio de Janeiro, RJ, Brazil.
Harm Reduction Initiative (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, Brazil
Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Oswaldo Cruz Foundation. Department of Health Information. Rio de Janeiro, RJ, Brazil.
Harm Reduction Initiative (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, Brazil
Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Resumo em Inglês
Background: Injecting drug users (IDU) have a key role in Hepatitis C Virus (HCV) epidemiology.
Young/short-term IDUs constitute a target group for preventive/harm reduction interventions.
Objectives: To investigate HCV transmission among young/short-term (ST) and long-term (LT) IDUs, from
the perspective of epidemiology and molecular biology.
Study design: Cross-sectional study assessing the prevalence of HCV infection/genotypes, as well as risk
behaviours/practices among IDUs from Rio de Janeiro. Phylogenetic analyses were performed and the
extent of segregation between sequences was quantified by the Association Index.
Results: ST were more likely to engage into needle-sharing (p = .021) and LT to attend Needle Exchange
Programs (p = .006). HCV prevalence was 10.1% vs. 23.4% among initiates and LT, respectively (p < .001).
Older age vs. imprisonment and longer duration of IDU career were independent predictors for HCV
infection among ST and LT, respectively. Among the latter, NEP attendance was inversely associated with
viral infection. HCV3a infectionswere the most prevalent. A moderate extent of phylogenetic segregation
between sequences was found, suggestive of transmission between IDU subgroups.
Conclusions: The lower HCV prevalence among young/short-term IDUs cannot be viewed with complacency,
due to their frequent engagement into direct/indirect sharing practices and the ongoing
transmission between IDU subsets. To avert new infections, preventive/harm reduction policies must
be tailored to empirical findings.
Palavras-chave em inglês
Injecting drug useSubstance abuse
Hepatitis C virus
HCV epidemiology
HCV subtypes
Phylogenetic analysis
Compartilhar