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SOLID PHARMACEUTICAL COMPOSITION OF DIDANOSINE
Blanver Farmoquímica Ltda. Brasil.
PCT
Europa
Brasil
Inventor(es)
Afiliación
Blanver Farmoquímica Ltda. Cotia, SP, Brasil.
Blanver Farmoquímica Ltda. Cotia, SP, Brasil.
Blanver Farmoquímica Ltda. Cotia, SP, Brasil.
Institución títular de la patente
Fundação Oswaldo Cruz. Brasil.Blanver Farmoquímica Ltda. Brasil.
Numero de deposito
PCT/IB2008/003527
Fecha de depósito
2008-11-13
Numero de depósito de la prioridad
ES200703002
Nmero de publicación
WO2009063320 A2
Fecha de publicación
2009-05-22
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EspanhaResumen en ingles
The present invention relates to a new solid pharmaceutical composition of didanosine comprising didanosine crystals with an average particle size comprised between 50 and 500 microns, coated by a layer of an enteric coating. The pharmaceutical composition of the invention can be prepared by means of a simple process, which comprises coating the didanosine crystals with an enteric layer. Said composition has a good stability of the active ingredient, as well as a suitable release in the conditions present in the upper part of the gastrointestinal tract. It also relates to the use of said composition for preparing solid dosage forms of didanosine for their oral administration. The invention also relates to tablets and to hard gelatin capsules containing said composition.
Numero IPC
A61K 9/16A61K 9/50A61K 31/505
Pais registro de la patente
EspanhaPCT
Europa
Brasil
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