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03 Saúde e Bem-EstarColecciones
- IOC - Artigos de Periódicos [12791]
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EVALUATION OF HAEMOPHILUS INFLUENZAE TYPE B CARRIER STATUS AMONG CHILDREN 10 YEARS AFTER THE INTRODUCTION OF HIB VACCINE IN BRAZIL
Nasopharyngeal carriage
Hib conjugate vaccine
Brazil
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Resumen en ingles
The aim of the present study was to assess the prevalence of Haemophilus influenzae type b (Hib) nasopharyngeal
(NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely
administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who
had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains
were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the
12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified
in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and
48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly
more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The
overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was
detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low
after 10 years of the introduction of the Hib vaccine.
Palabras clave en ingles
Haemophilus influenzae type bNasopharyngeal carriage
Hib conjugate vaccine
Brazil
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