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DISSEMINATED LEISHMANIASIS: A NEW AND EMERGING FORM OF LEISHMANIASIS OBSERVED IN NORTHEASTERN BRAZIL.
Leishmaniose Tegumentar Difusa/epidemiologia
Adulto
Idoso
Agricultura
Animais
Brasil/epidemiologia
Feminino
Humanos
Interferon gama/biossíntese
Leishmaniose Tegumentar Difusa/diagnóstico
Leishmaniose Mucocutânea/diagnóstico
Leucócitos Mononucleares/metabolismo
Masculino
Meia-Idade
Membrana Mucosa/patologia
Prevalência
Fatores de Risco
Pele/patologia
Fator de Necrose Tumoral alfa/biossíntese
Autor
Afiliación
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD
Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Resumen en ingles
During the past decade, there has been an increase in the number of patients with disseminated leishmaniasis (DL), which is characterized by a large number of acneiform and papular skin lesions, with very few or no parasites in the skin tissue. The present report describes 42 cases of DL identified between 1992 and 1998 in an area where Leishmania braziliensis transmission is endemic; 8 of the patients were prospectively diagnosed. In a contrast to localized cutaneous leishmaniasis (LCL), acquisition of DL was associated with age >19 years (P<.05), male sex (P<.05), and agricultural occupation (P<.001). Patients with DL presented with 10-300 lesions that were a mixture of acneiform, papular, nodular, and ulcerated types. Twelve (29%) of 42 patients had mucosal involvement. Patients with DL had lower levels of interferon-gamma (P<.05) and tumor necrosis factor-alpha (P<.05) production, compared with patients with LCL. DL is an emerging clinical distinct form of leishmaniasis associated with agricultural activities and host immunological response
DeCS
Leishmania braziliensisLeishmaniose Tegumentar Difusa/epidemiologia
Adulto
Idoso
Agricultura
Animais
Brasil/epidemiologia
Feminino
Humanos
Interferon gama/biossíntese
Leishmaniose Tegumentar Difusa/diagnóstico
Leishmaniose Mucocutânea/diagnóstico
Leucócitos Mononucleares/metabolismo
Masculino
Meia-Idade
Membrana Mucosa/patologia
Prevalência
Fatores de Risco
Pele/patologia
Fator de Necrose Tumoral alfa/biossíntese
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