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WHOLE-GENOME SEQUENCE OF SCHISTOSOMA HAEMATOBIUM
Young, Neil D et al. | Data do documento: 2012
Autor(es)
Young, Neil D
Jex, Aaron R
Cantacessi, Cinzia
Hall, Ross S
Hofmann, Andreas
Campbell, Bronwyn E
Gasser, Robin B
Li, Bo
Liu, Shiping
Yang, Linfeng
Xiong, Zijun
Li, Yingrui
Xu, Xun
Chen, Fangyuan
Wu, Xuan
Zhang, Guojie
Fang, Xiaodong
Kang, Yi
Yang, Huanming
Wang, Jun
Wang, Jian
Zerlotini Neto, Adhemar
Oliveira, Guilherme Corrêa de
Hofmann, Andreas
Loukas, Alex
Ranganathan, Shoba
Rollinson, David
Rinaldi, Gabriel
Brindley, Paul J
Afiliação
University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
University of Melbourne. Faculty of Veterinary Science. Victoria, Australia.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
BGI–Shenzhen. Shenzhen, China.
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil.
Griffith University. Eskitis Institute for Cell & Molecular Therapies. Brisbane, Queensland, Australia.
James Cook University. Tropical Medicine and Rehabilitation Sciences. School of Public Health. Cairns, Queensland, Australia.
Macquarie University. Department of Chemistry and Biomolecular Sciences. Sydney, New South Wales, Australia/ National University of Singapore. Department of Biochemistry. Singapore.
Natural History Museum. London, UK.
Universidad de la República. Departamento de Genética. Montevideo, Uruguay/ George Washington University. Department of Microbiology, Immunology & Tropical Medicine. Washington, DC, USA.
George Washington University. Department of Microbiology, Immunology & Tropical Medicine. Washington, DC, USA.
Resumo em Inglês
Schistosomiasis is a neglected tropical disease caused by blood flukes (genusSchistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobiumhas come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancerand as a predisposing factor for HIV/AIDS.The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions
Palavras-chave em inglês
Schistosomiasis
blood flukes
Praziquantel
 
Editor
Nature Publishing Group
Referência
YOUNG, Neil D et al. Whole-genome sequence of Schistosoma haematobium. Nature Genetics, vol.44, n. 2, p. 221-225, 2012.
DOI
10.1038/ng.1065
ISSN
1061-4036