Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men

Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, USA
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil
University of Cologne. Institute for Genetics. Cologne, Germany
University of Cologne. Institute for Genetics. Cologne, Germany/Instituto Gulbenkian de Ciencia. Oeiras, Portugal
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA

Resumo em Inglês

Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed.

Palavras-chave em inglês

Toxoplasma gondii

Editor

Cell Press

Referência

GAZZINELLI, Ricardo Tostes et al. Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men. Cell Host Microbe, vol. 15, n. 2, p. 132-8. 2014

DOI

10.1016/j.chom.2014.01.004

ISSN

1931-3128

Use este identificador para citar ou linkar para este item: https://www.arca.fiocruz.br/handle/icict/11397

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Direito Autoral

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