Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/11220
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Objetivos de Desenvolvimento Sustentável
05 Igualdade de gêneroColeções
- IOC - Artigos de Periódicos [12747]
Metadata
Mostrar registro completo
INCREASING HETEROSEXUAL TRANSMISSION OF HIV-1 SUBTYPE C IN INLAND CENTRAL WESTERN BRAZIL
Autor(es)
Afiliação
Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil.
Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil.
Resumo em Inglês
The molecular epidemiology of HIV-1 in Brazil is
complex and heterogeneous because several
subtypes co-circulate with some important regional
differences. This study evaluated HIV-1
subtypes amongst pregnant women living in the
metropolitan area and in the interior cities from
central western Brazil. From June 2008 to June
2010, 86.9% of confirmed cases of HIV-1 infection
amongst pregnant women (172 out of 198 cases)
were recruited in Goiania/Goias state. The HIV-1
pol gene was sequenced after nested-PCR. HIV-1
subtypes were assigned by REGA, phylogenetic,
and bootscan analyses. The median age of participants
was 26 years (15–41 years range); 58.7%
of participants were diagnosed during prenatal
care and 51.7% of participants came from >50
interior cities within Goias state. Amongst the
131 HIV-1 pol sequences, 64.9% were subtype B,
13.0% were BF1 recombinant, 11.4% were
subtype C, 7.6% were subtype F1, and 2.3% were
BC recombinant. According to the HIV-1 diagnosis
date (1994–2010), a significant increase
in subtype C and a decrease of BF1 mosaics
were observed over time. All subtype C patients
lived in interior cities where the highest prevalence
of subtype C outside southern Brazil
was observed (18.4%). Phylogenetic analysis
revealed multiple independent introductions of
the Brazilian subtype C clade from the southern/
southeastern regions of Brazil. The HIV-1 epidemic
in women from central western Brazil
infected by the heterosexual route is characterized
by an unexpectedly high prevalence of subtype
C viruses highly related to those circulating
in southern/southeastern Brazil. These findings
highlight the importance of molecular surveillance
programs outside large metropolitan
regions in Brazil.
Compartilhar