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https://www.arca.fiocruz.br/handle/icict/11209
ANTITUMOR PROPERTIES OF THE ESSENTIAL OIL FROM THE LEAVES OF DUGUETIA GARDNERIANA.
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Federal University of Sergipe. Department of Biology. São Cristovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Propedêutica. Salvador, BA, Brasil
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Federal University of Sergipe. Department of Biology. São Cristovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Propedêutica. Salvador, BA, Brasil
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Resumo em Inglês
Duguetia gardneriana, popularly known in the
Brazilian northeast as “jaquinha”, is a species belonging
to the family Annonaceae. The aim of this
work was to assess the chemical composition and
antitumor properties of the essential oil from the
leaves of D. gardneriana in experimental models.
The chemical composition of the essential oil was
analyzed via gas chromatography-flame ionization
detector and gas chromatography-mass
spectrometry. In vitro cytotoxic activity was determined
in cultured tumor cells, and in vivo antitumor
activity was assessed in B16-F10-bearing
mice. The identified compounds were β-bisabolene
(80.99%), elemicin (8.04%), germacrene D
(4.15%), and cyperene (2.82%). The essential oil
exhibited a cytotoxic effect, with IC50 values of
16.89, 19.16, 13.08, and 19.33 μg/mL being obtained
for B16-F10, HepG2, HL-60, and K562 cell
lines, respectively. On the other hand, β-bisabolene
was inactive in all of the tested tumor cell
lines (showing IC50 values greater than 25 μg/
mL). The in vivo analysis revealed tumor growth
inhibition rates of 5.37–37.52% at doses of 40
and 80mg/kg/day, respectively. Herein, the essential
oil from the leaves of D. gardneriana presented
β-bisabolene as the major constituent and
showed cytotoxic and antitumor potential.
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