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MULTICENTER CASE–CONTROL STUDY PROTOCOL OF PNEUMONIA ETIOLOGY IN CHILDREN: GLOBAL APPROACH TO BIOLOGICAL RESEARCH, INFECTIOUS DISEASES AND EPIDEMICS IN LOW-INCOME COUNTRIES (GABRIEL NETWORK)
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Abstract
Background: Data on the etiologies of pneumonia among children are inadequate, especially in developing countries.
The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized
with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia
while assessing individual and microbial factors associated with the risk of severe pneumonia.
Methods/design: A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are
located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay.
At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized
children <5 years with radiologically confirmed pneumonia, and the controls are children without any features
suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5
bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens
are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between
procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen
identification in undiagnosed samples.
Discussion: This multicenter study will provide descriptive results for better understanding of pathogens responsible
for pneumonia among children in developing countries. The identification of determinants related to microorganisms
associated with pneumonia and its severity should facilitate treatment and prevention.
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