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EXPRESSION OF KI-67, P53 AND P63 PROTEINS IN KERATOCYST ODONTOGENIC TUMOURS: AN IMMUNOHISTOCHEMICAL STUDY.
Keratocyst odontogenic tumour
Cell proliferation
Ki-67
p53
p63
Cistos Odontogênicos/metabolismo
Tumores Odontogênicos/metabolismo
Transativadores/metabolismo
Proteína Supressora de Tumor p53/metabolismo
Anticorpos
Contagem de Células
Humanos
Imuno-Histoquímica
Cistos Odontogênicos/patologia
Tumores Odontogênicos/patologia
Fatores de Transcrição
Autor
Afiliación
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Division of Oral Radiology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Division of Oral Radiology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil
Resumen en ingles
Abstract Aim To investigate the immunohistochemical
expression of Ki-67, p53 and p63 in Keratocyst Odontogenic
Tumours (KOTs) in order to contribute to the
biological profile of this tumor. Methods Immunohistochemical
technique was performed using the EnVisionTM
System in 37 cases of KOTs. Results Ki-67- and p53-
immunostained cells were mainly located in the suprabasal
layers. p63-positive cells were found throughout the lining
cystic epithelium. No difference in the immunostaining for
these proteins was observed between primary and recurrent
KOTs (Ki-67: P = 0.5591; p53: P = 0.9847; p63:
P = 0.9127), or between KOTs associated with Nevoid
Basal Cell Carcinoma Syndrome (NBCCS) and sporadic
KOTs (Ki-67: P = 0.7013; p53: P = 0.3197; p63:
P = 0.2427). Conclusions It is possible that biological
behavior of KOTs may be related to suprabasal proliferative
compartment in the cystic epithelium as observed by
high levels of Ki-67, p53 and p63. In addition, p63
immunostaining may represent immaturity of keratinocytes
in KOTs, and suggests that this protein may participate in
the regulation of epithelial cell differentiation. Taken
together, these data may favor tumorigenesis on KOTs.
Palabras clave en ingles
Odontogenic cystsKeratocyst odontogenic tumour
Cell proliferation
Ki-67
p53
p63
DeCS
Antígeno Ki-67/metabolismoCistos Odontogênicos/metabolismo
Tumores Odontogênicos/metabolismo
Transativadores/metabolismo
Proteína Supressora de Tumor p53/metabolismo
Anticorpos
Contagem de Células
Humanos
Imuno-Histoquímica
Cistos Odontogênicos/patologia
Tumores Odontogênicos/patologia
Fatores de Transcrição
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