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PHYLOGENETIC ANALYSES OF NOROVIRUS STRAINS DETECTED IN URUGUAY REVEAL THE CIRCULATION OF THE NOVEL GII.P7/GII.6 RECOMBINANT VARIANT
Autor
Afiliación
Universidad de la República. Facultad de Ciencias. Centro de Investigaciones Nucleares. Laboratorio de Virología Molecular. Montevideo, Uruguay.
Universidad de la República. Regional Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
Universidad de la República. Regional Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil.
Universidad de la República. Facultad de Ciencias. Centro de Investigaciones Nucleares. Laboratorio de Virología Molecular. Montevideo, Uruguay.
Universidad de la República. Regional Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
Universidad de la República. Regional Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
Universidad de la República. Regional Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil.
Universidad de la República. Facultad de Ciencias. Centro de Investigaciones Nucleares. Laboratorio de Virología Molecular. Montevideo, Uruguay.
Universidad de la República. Regional Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
Resumen en ingles
Noroviruses (NoV) are one of the major etiological agent of acute gastroenteritis (AGE) outbreaks worldwide.
Distinct NoV genotypes have been associated with different transmission patterns and disease
severity in humans. Therefore, it is important to identify genetically different NoV genotypes circulating
in a particular region. However, genotyping has become a challenge due to recombination events occurring
mainly nearby ORF1/ORF2 junction of NoV genome, leading to distinct genotypes with polymerase
and capsid regions derived from parenteral strains. Taking this into account, ORF1/ORF2 sequences were
obtained from NoV strains collected from patients with AGE in Uruguay. This study reveals in silico evidences
of recombination events taking place in four out of six strains analyzed for which its polymerase
gene and its capsid region correspond to GII.P7 and to GII.6 genotype, respectively. These results also
reveal the circulation of a GII.P7/GII.6 recombinant variant in the natural populations of NoV strains in
the northwestern region of Uruguay. As far as we know this is the first report about the circulation of
a NoV GII.P7/GII.6 recombinant variant in the Americas.
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