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PROGRAMMED NECROSIS IN THE CROSS TALK OF CELL DEATH AND INFLAMMATION
RIPK1
RIPK3
MLKL
TNF
Inflammation
TRIF
DAI,
MCMV
Vaccinia virus
Afiliación
University of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts
University of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts
University of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of Massachusetts Medical School. Department of Pathology, Immunology and Microbiology Program. Worcester, Massachusetts
Resumen en ingles
Cell proliferation and cell death are integral elements in maintaining homeostatic balance in metazoans. Disease pathologies ensue when these processes are disturbed. A plethora of evidence indicates that malfunction of cell death can lead to inflammation, autoimmunity, or immunodeficiency. Programmed necrosis or necroptosis is a form of nonapoptotic cell death driven by the receptor interacting protein kinase 3 (RIPK3) and its substrate, mixed lineage kinase domain-like (MLKL). RIPK3 partners with its upstream adaptors RIPK1, TRIF, or DAI to signal for necroptosis in response to death receptor or Toll-like receptor stimulation, pathogen infection, or sterile cell injury. Necroptosis promotes inflammation through leakage of cellular contents from damaged plasma membranes. Intriguingly, many of the signal adaptors of necroptosis have dual functions in innate immune signaling. This unique signature illustrates the cooperative nature of necroptosis and innate inflammatory signaling pathways in managing cell and organismal stresses from pathogen infection and sterile tissue injury.
Palabras clave en ingles
NecroptosisRIPK1
RIPK3
MLKL
TNF
Inflammation
TRIF
DAI,
MCMV
Vaccinia virus
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