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INTEGRIN ADB2 (CD11D/CD18) IS EXPRESSED BY HUMAN CIRCULATING AND TISSUE MYELOID LEUKOCYTES AND MEDIATES INFLAMMATORY SIGNALING
Mediates Inflammatory Signaling
Human Circulating
Integrin αDβ2 (CD11d/CD18)
Autor
Afiliación
Tokyo Medical and Dental University. Department of Respiratory Medicine. Tokio, Japan.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / University of Utah School of Medicine. Program in Molecular Medicine. Salt Lake City, Utah, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / University of Utah School of Medicine. Program in Molecular Medicine. Salt Lake City, Utah, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.
University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, Utah, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Immunofarmacologia. Rio de Janeiro. RJ, Brasil.
Resumen en ingles
Integrin aDb2 is the most recently identified member of the leukocyte, or b2,
subfamily of integrin heterodimers. Its distribution and functions on human
leukocytes have not been clearly defined and are controversial. We examined
these issues and found that aDb2 is prominently expressed by leukocytes in whole
blood from healthy human subjects, including most polymorphonuclear leukocytes
and monocytes. We also found that aDb2 is displayed by leukocytes in the alveoli of
uninjured and inflamed human lungs and by human monocyte-derived
macrophages and dendritic cells, indicating broad myeloid expression. Using
freshly-isolated human monocytes, we found that aDb2 delivers outside-in signals to
pathways that regulate cell spreading and gene expression. Screening expression
analysis followed by validation of candidate transcripts demonstrated that
engagement of aDb2 induces mRNAs encoding inflammatory chemokines and
cytokines and secretion of their protein products. Thus, aDb2 is a major member of
the integrin repertoire of both circulating and tissue myeloid leukocytes in humans.
Its broad expression and capacity for outside-in signaling indicate that it is likely to
have important functions in clinical syndromes of infection, inflammation, and tissue
injury.
Palabras clave en ingles
Tissue Myeloid LeukocytesMediates Inflammatory Signaling
Human Circulating
Integrin αDβ2 (CD11d/CD18)
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