Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/10501
TEGUMENTAL CHANGES IN ADULT SCHISTOSOMA MANSONI INDUCED BY A NEW IMIDAZOLIDINIC DERIVATIVE
Autor(es)
Silva, Anekécia Lauro da
Oliveira, Sheilla Andrade de
Oliveira, Jamerson Ferreira de
Santiago, Edna de Farias
Almeida Júnior, Antônio Sérgio Alves
Jacobi, Íris Trindade Tenório
Peixoto, Christina Alves
Rocha, Vinícius Pinto Costa
Soares, Milena Botelho Pereira
Pitta, Ivan da Rocha
Lima, Maria do Carmo Alves de
Oliveira, Sheilla Andrade de
Oliveira, Jamerson Ferreira de
Santiago, Edna de Farias
Almeida Júnior, Antônio Sérgio Alves
Jacobi, Íris Trindade Tenório
Peixoto, Christina Alves
Rocha, Vinícius Pinto Costa
Soares, Milena Botelho Pereira
Pitta, Ivan da Rocha
Lima, Maria do Carmo Alves de
Afiliação
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Laboratório of Immunology and Molecular Biology. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Laboratório of Immunology and Molecular Biology. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Ultraestrutura. Departmento de Entomologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Laboratório of Immunology and Molecular Biology. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Aggeu Magalhães. Laboratório of Immunology and Molecular Biology. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Ultraestrutura. Departmento de Entomologia. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Federal University of Pernambuco. Institute of Biology. Department of Antibiotics. Recife, PE, Brasil
Resumo em Inglês
Aims: Verify the potential of the schistosomicidal imidazolidine derivative (5Z)-3-(4-
bromo-benzyl)-5-(4-chloro-benzylidene)-4-thioxo-imidazolidin-2-one.
Study Design: In this study, we tested the imidazolidinic derivative 3 through in vitro
evaluations, cytotoxicity assay and analysis of Scanning Electron Microscopy to verify its
therapeutic potential in the treatment of schistosomiasis.
Place and Duration of Study: Departamento de Antibióticos, Universidade Federal de
Pernambuco (UFPE), Fundação Oswaldo Cruz (FIOCRUZ)/PE and (FIOCRUZ)/BA
between January 2013 and march 2014.
Methodology: This study was approved by the Ethics Committee on Animal Use
Research Center Aggeu Magalhães/Oswaldo Cruz Fundação (CPqAM/FIOCRUZ)
authorized by the license No. 21/2011. Male albino Swiss mice were used Mus musculus
25 days old weighing 50 grams. Compound 3 was assayed for its cytotoxicity through cell
J774 macrophage lineage. The amount of inhibitory concentration (LC50) was determined
by nonlinear regression using the Graph Pad Prism version 5.01. Then the compound
was evaluated against adult worms of S. mansoni by performing the activity in vitro at
doses 100-20μg/mL and ultrastructural investigation by Scanning Electron Microscopy
(SEM) at doses of 100 and 60μg/ml. The PZQ was the positive control of the experiment.
Results: The derivative 3 showed LC50 of 29.7±3.9mM. Compound 3 was able to have
decreased motility of S. mansoni culminating with a mortality rate of 100% at doses of 60
and 100μg/mL on the fourth day of observation of the experiment. In the SEM, the
compound caused various soft tissue changes of S. mansoni parasites such as blistering,
destruction of the integument with loss of spines and tubercles, body contraction and
windy.
Conclusion: The derivative imidazolidine 3 showed a promising schistosomicidal activity
in vitro. However, conducting further studies with the completion of work in front of the live
schistosomiasis is required.
Compartilhar