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WHY STRATEGIES TO CONTROL LEISHMANIA SPP. MULTIPLICATION BASED ON THE USE OF PROTEINASE INHIBITORS SHOULD CONSIDER MULTIPLE TARGETS AND NOT ONLY A SINGLE ENZYME
Alves, Carlos Roberto et al. | Date Issued: 2014
Author
Alves, Carlos Roberto
Pereira, Bernardo Acácio Santini
Almeida, Mariana Silva
Silva, Franklin Souza da
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
Abstract
The use of proteinases as targets to develop novel chemotherapies against Leishmania spp. infections is a very promising strategy. Based on a previous study by Goyal et al. [J MolModel (2014) 20:2099], we discuss herein the idea that only a combined treatment with distinct proteinase inhibitors would be an effective antileishmanial therapy.
Keywords in Portuguese
Leishmania
Keywords
Leishmania
Oligopeptidase B
Proteinase inhibitors
Antileishmanial therapy
 
Keywords in Spanish
Leishmania
Publisher
Springer Link
Citation
ALVES, Carlos Roberto et al. Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme.J Mol Model, v. 20, n.2465, 6p, 2014.
DOI
10.1007/s00894-014-2465-4