Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/10093
Tipo de documento
ArtigoDireito Autoral
Acesso aberto
Objetivos de Desenvolvimento Sustentável
3 Saúde e Bem-EstarColeções
- IOC - Artigos de Periódicos [12678]
Metadata
Mostrar registro completo
TCI/TCII CO-INFECTION CAN ENHANCE TRYPANOSOMA CRUZI GROWTH IN RHODNIUS PROLIXUS
Tcl
Tdl
Mixed Infections
Rhodnius prolixus
Digestive tract
Chagas Disease
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil
Resumo em Inglês
Background: Rhodnius prolixus is an obligate haematophagous insect and one of the most important vectors of
Trypanosoma cruzi, the causative agent of Chagas disease in the Americas. T. cruzi is a highly variable parasite which
is not transmitted in the same efficiency by the different triatomine vectors. Because different T. cruzi genotypes are
aetiopathologically divergent, further elucidation of the transmission abilities of different Chagas disease vectors is
extremely important.
Findings: In the present study, the growth behaviour of two T. cruzi isolates, MDID/BR/1993/C45 (TcI) and TBRA/BR/
1999/JCA3 (TcII), sharing the same microhabitat (intestinal tract) in single and mixed infections, was examined. The
distribution patterns and parasite population densities were evaluated at 7, 14 and 21 days after feeding (daf) by
quantification of parasites using Neubauer haemocytometric measurements and mini-exon PCR to identify TcI and
TcII subpopulations. Parasitic colonization in the small intestine was more successful in the mixed infection model
than the single infection models at 21 daf. In the rectal lumen and wall, the growth behaviour of the mixed infection
was similar to that of the TcI group, although the total parasite number was lower. In the TcII group, no metacyclic
trypomastigote forms were found. PCR analysis of the contents of each dissected region showed different genotype
fractions in the mixed infection model, in which TcI seemed to be the predominant isolate.
Conclusion: The different growth behaviour of the TcI and TcII isolates in single and mixed infection models
demonstrated that possibly an intraspecific factor modulates parasitic development in the intestine of R. prolixus.
Palavras-chave em inglês
Trypanosoma cruziTcl
Tdl
Mixed Infections
Rhodnius prolixus
Digestive tract
Chagas Disease
Compartilhar