Author | Lanzaro, G. C | |
Author | Lopes, Angela Hampshire de Carvalho Santos | |
Author | Ribeiro, José Marcos Chaves | |
Author | Shoemaker, Charles B | |
Author | Warburg, A | |
Author | Soares, Milena Botelho Pereira | |
Author | Titus, Richard G | |
Access date | 2015-04-07T14:02:23Z | |
Available date | 2015-04-07T14:02:23Z | |
Document date | 1999 | |
Citation | LANZARO, G. C. et al. Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. Insect Molecular Biology, v. 8, n. 2, p. 267-275, 1999. | pt_BR |
ISSN | 0962-1075 | |
URI | https://www.arca.fiocruz.br/handle/icict/9909 | |
Language | eng | pt_BR |
Publisher | Blackwell Science | pt_BR |
Rights | open access | pt_BR |
Title | Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex. | pt_BR |
Type | Article | pt_BR |
Abstract | Maxadilan is an approximately 7kDa peptide that occurs in the saliva of the sand fly Lutzomyia longipalpis. This peptide is a potent vasodilator and may also have immunomodulatory effects related to the pathogenesis of leishmanial infections. Variation in the primary DNA and inferred amino acid sequence of maxadilan is reported. Differences were found within and among natural field populations as well as among sibling species. Extensive amino acid sequence differentiation, up to 23%, was observed among maxadilan from different populations. This is a remarkable degree of polymorphism considering the small size of this peptide. The vasodilatory activity of maxadilan was equivalent among recombinant maxadilan variants. All maxadilan variants induce interleukin-6. Predicted secondary structure and hydrophobicity plots suggest that these characteristics are conserved among variant peptides. However, profiles based on the antigenic index do differ among peptides. | pt_BR |
Affilliation | University of Texas Medical Branch. University Boulevard. Department of Pathology & Center for Tropical Diseases. Galveston, USA | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | National Institute for Health and Welfare. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA | pt_BR |
Affilliation | Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA | pt_BR |
Affilliation | Hebrew University-Hadassah Medical School. Ein Kerem, Jerusalem, Israel | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Colorado State University. College of Veterinary Medicine & Biomedical Sciences. Fort Collins, CO, USA | pt_BR |
Subject | Maxadalin | pt_BR |
Subject | Population genetics | pt_BR |
Subject | Saliva | pt_BR |
Subject | Vasodilator | pt_BR |
DeCS | Proteínas de Insetos/farmacologia | pt_BR |
DeCS | Psychodidae | pt_BR |
DeCS | Proteínas e Peptídeos Salivares/farmacologia | pt_BR |
DeCS | Vasodilatadores/farmacologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Sequência de Bases | pt_BR |
DeCS | DNA | pt_BR |
DeCS | Proteínas de Insetos/química | pt_BR |
DeCS | Interleucina-6/biossíntese | pt_BR |
DeCS | Macrófagos Peritoneais/efeitos de drogas | pt_BR |
DeCS | Dados de Sequência Molecular | pt_BR |
DeCS | Estrutura Secundária de Proteína | pt_BR |
DeCS | Coelhos | pt_BR |
DeCS | Proteínas e Peptídeos Salivares/química | pt_BR |
DeCS | Vasodilatadores/química | pt_BR |
DeCS | Vasodilatadores/classificação | pt_BR |