Author | Carvalho, Antonio Carlos Campos de | |
Author | Goldenberg, Regina Coeli dos Santos | |
Author | Jelicks, Linda A | |
Author | Soares, Milena Botelho Pereira | |
Author | Santos, Ricardo Ribeiro dos | |
Author | Spray, David Conover | |
Author | Tanowitz, Herbert Bernard | |
Access date | 2015-04-06T18:20:03Z | |
Available date | 2015-04-06T18:20:03Z | |
Document date | 2009 | |
Citation | CARVALHO, A. C. C. etal. Cell therapy in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases, p. 484358-6, 2009. | pt_BR |
ISSN | 1687-708X | |
URI | https://www.arca.fiocruz.br/handle/icict/9902 | |
Language | eng | pt_BR |
Publisher | Hindawi Publishing Corporation | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Doença de chagas | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Cardiomiopatia | pt_BR |
Subject in Portuguese | America Latina | pt_BR |
Subject in Portuguese | Miocardiopatia chagásica | pt_BR |
Subject in Portuguese | Cirurgia | pt_BR |
Subject in Portuguese | Transplante de células | pt_BR |
Subject in Portuguese | Transplante da medula óssea | pt_BR |
Subject in Portuguese | Animais | pt_BR |
Title | Cell therapy in Chagas Disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2009/484358 | |
Abstract | Chagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In
later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy. In
these individuals heart transplantation has been attempted. However, this procedure is fraught with many problems attributable
to the surgery and the postsurgical administration of immunosuppressive drugs. Studies inmice suggest that the transplantation of
bone-marrow-derived cells ameliorates the inflammation and fibrosis in the heart associated with this infection. Cardiac magnetic
resonance imaging reveals that bone marrow transplantation ameliorates the infection induced right ventricular enlargement. On
the basis of these animal studies the safety of autologous bone marrow transplantation has been assessed in patients with chagasic
end-stage heart disease. The initial results are encouraging and more studies need to be performed. | pt_BR |
Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Albert Einstein College of Medicine. Department of Physiology & Biophysics. Bronx, NY, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA | pt_BR |
Affilliation | Albert Einstein College of Medicine. Department of Pathology. Bronx, NY, USA | pt_BR |