Author | Carvalho, Augusto M | |
Author | Cristal, Juqueline Rocha | |
Author | Muniz, Aline de Couto | |
Author | Carvalho, Lucas Pedreira de | |
Author | Gomes, Regis | |
Author | Miranda, José Carlos | |
Author | Barral, Aldina Maria Prado | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Oliveira, Camila Indiani de | |
Access date | 2015-03-09T17:51:38Z | |
Available date | 2015-03-09T17:51:38Z | |
Document date | 2015 | |
Citation | CARVALHO, A. M. et al. Interleukin 10-dominant immune response and increased risk of Cutaneous Leishmaniasis after natural exposure to Lutzomyia intermedia Sand Flies. Journal of Infectious Diseases, fevereiro 2015. | pt_BR |
ISSN | 0022-1899 | |
URI | https://www.arca.fiocruz.br/handle/icict/9665 | |
Language | eng | pt_BR |
Publisher | University of Chicago Press | pt_BR |
Rights | open access | pt_BR |
Title | Interleukin 10-Dominant Immune Response and Increased Risk of Cutaneous Leishmaniasis After Natural Exposure to Lutzomyia intermedia Sand Flies | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jiv020 | |
Abstract | Leishmaniasis is caused by parasites transmitted to the vertebrate host by infected sand flies. During
transmission, the vertebrate host is also inoculated with sand fly saliva, which exerts powerful immunomodulatory
effects on the host’s immune response.
Methods. We conducted a prospective cohort analysis to characterize the human immune response to Lutzomyia
intermedia saliva in 264 individuals, from an area for cutaneous leishmaniasis (CL) caused by Leishmania
braziliensis.
Results. Antibodies were found in 150 individuals (56.8%); immunoglobulin G1 and G4 were the predominant
subclasses. Recall responses to salivary gland sonicate showed elevated production of interleukin 10 (IL-10), interleukin
13, interferon γ, CXCL9, and CCL2 compared with controls. CD4+CD25+ T cells, including Foxp3+ cells, were the main
source of IL-10. L. braziliensis replication was increased (P < .05) in macrophages cocultured with saliva-stimulated
lymphocytes from exposed individuals and addition of anti–IL-10 reverted this effect. Positive correlation between antibody
response to saliva and cellular response to Leishmania was not found. Importantly, individuals seropositive to
saliva are 2.1 times more likely to develop CL (relative risk, 2.1; 95% confidence interval, 1.07–4.2; P < .05).
Conclusions. Exposure to L. intermedia sand flies skews the human immune response, facilitating L. braziliensis
survival in vitro, and increases the risk of developing CL. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil | pt_BR |
Subject | Sand fly saliva | pt_BR |
Subject | L. braziliensis | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | Lutzomyia intermedia | pt_BR |
Subject | ELISA | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Chemokines | pt_BR |