Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/9495
Title: Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauı´, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil
Authors: Figueiredo, Leandra Barcelos
Sakamoto, Tetsu
Coelho, Luiz Felipe Leomil
Rocha, Eliseu Soares de Oliveira
Cota, Marcela Menezes Gomes
Ferreira, Gustavo Portela
Oliveira, Jaquelline Germano de
Kroon, Erna Geessien
Affilliation: Universidade Federal de Minas Gerais. Departamento de Microbiologia. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Laboratorio de Biodados. Belo Horizonte, MG, Brazil
Universidade Federal de Alfenas. Laboratorio de Vacinas. Alfenas, MG, Brazil
Universidade Federal de Minas Gerais. Laboratorio de Vırus. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Laboratorio de Vırus. Belo Horizonte, MG, Brazil
Universidade Federal do Piauı. Laboratorio de Biotecnologia. Parnaıba, PI, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, Brazil
Abstract: Dengue virus (DENV) is the most widespread arthropod-borne virus, and the number and severity of outbreaks has increased worldwide in recent decades. Dengue is caused by DENV-1, DENV- 2, DENV-3 and DENV-4 which are genetically distant. The species has been subdivided into genotypes based on phylogenetic studies. DENV-2, which was isolated from dengue fever patients during an outbreak in Piaui, Brazil in 2006/2007 was analyzed by sequencing the envelope (E) gene. The results indicated a high similarity among the isolated viruses, as well as to other DENV-2 from Brazil, Central America and South America. A phylogenetic and phylogeographic analysis based on DENV-2E gene sequences revealed that these viruses are grouped together with viruses of the American-Asian genotype in two distinct lineages. Our results demonstrate the co-circulation of two American-Asian genotype lineages in northeast Brazil. Moreover, we reveal that DENV-2 lineage 2 was detected in Piauí before it disseminated to other Brazilian states and South American countries, indicating the existence of a new dissemination route that has not been previously described.
Keywords: Dengue vírus
Elisa PCR
LANL
Hemorrhagic Fever
Virus sequence database
Issue Date: 2014
Publisher: Public Library of Science
Citation: FIGUEIREDO, Leandra Barcelos. Dengue Virus 2 American-Asian Genotype Identified during the 2006/2007 Outbreak in Piauı, Brazil Reveals a Caribbean Route of Introduction and Dissemination of Dengue Virus in Brazil. PLoS ONE, v. 9, n. 8, p. e104516. 2014
DOI: 10.1371/journal.pone.0104516
ISSN: 1553-7366
Copyright: open access
Appears in Collections:IRR - Artigos de Periódicos

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