Author | Costa, Allyson Guimarães da | |
Author | Antonelli, Lis Ribeiro do Valle | |
Author | Costa, Pedro Augusto Carvalho | |
Author | Pimentel, João Paulo Diniz | |
Author | Garcia, Nadja Pinto | |
Author | Tarragô, Andréa Monteiro | |
Author | Santos, Maria do Perpétuo Socorro Lopes dos | |
Author | Nogueira, Paulo Afonso | |
Author | Hekcmann, Maria Izabel Ovellar | |
Author | Sadahiro, Aya | |
Author | Carvalho, Andréa Teixeira | |
Author | Martins Filho, Olindo Assis | |
Author | Malheiro, Adriana | |
Access date | 2015-02-09T16:50:34Z | |
Available date | 2015-02-09T16:50:34Z | |
Document date | 2014 | |
Citation | COSTA, Allyson Guimarães et al. The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6/IL-10 Axis and Is Associated with the Parasite Load. Journal of Immunology Research, V.4, Article ID 318250, 11 pages, 2014. | pt_BR |
ISSN | 2314-7156 | |
URI | https://www.arca.fiocruz.br/handle/icict/9462 | |
Language | eng | pt_BR |
Publisher | Hindawi Publishing Corporation | pt_BR |
Rights | open access | pt_BR |
Title | The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6/IL-10 Axis and Is Associated with the Parasite Load | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2014/318250 | |
Abstract | Background. Recent studies have shown that the inflammatory process, including the biomarker production, and the intense activation of innate immune responses are greater in the malaria caused by Plasmodium vivax than other species. Here, we examined the levels of serum biomarkers and their interaction during acute malaria.
Material and Methods. Blood samples were collected from P. vivax-infected patients at admission and from healthy donors. Levels of serum biomarkers were measured by Cytometric Bead Assay or ELISA.
Results.P. vivax infection triggered the production of both inflammatory and regulatory biomarkers. Levels of IL-6, CXCL-8, IFN-γ, IL-5, and IL-10 were higher in P. vivax-infected patients than in healthy donors. On the other hand, malaria patients produced lower levels of TNF-α, IL-12p70, and IL-2 than healthy individuals. While the levels of IL-10 and IL-6 were found independent on the number of malaria episodes, higher levels of these cytokines were seen in patients with higher parasite load.
Conclusion. A mixed pattern of proinflammatory and regulatory biomarkers is produced in P. vivax malaria. Analysis of biomarker network suggests that IL-10 and IL-6 are a robust axis in malaria patients and that this interaction seems to be associated with the parasite load. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Medicina Tropical de Coari. Coari, AM, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil | pt_BR |
Subject | Malária | pt_BR |
Subject | Plasmodium vivax | pt_BR |
Subject | ELISA | pt_BR |