Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/9031
Title: The levels of IL-17A and of the cytokines involved in the Th17 cell commitment are increased in patients with chronic immune thrombocytopenia
Authors: Rocha, Andreia Maria Camargos
Souza, Cláudia
Rocha, Gifone Aguiar
Melo, Fabrício Freire de
Clementino, Nelma Cristina Diogo
Marino, Marília Campos Abreu
Bozzi, Adriana
Silva, Maria Luiza
Martins Filho, Olindo Assis
Queiroz, Dulciene Maria Magalhães
Affilliation: Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisa em Bacteriologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Hospital Universitário. Serviço de Hematologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisa em Bacteriologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisa em Bacteriologia. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Hospital Universitário. Serviço de Hematologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Laboratório de Pesquisa em Bacteriologia. Belo Horizonte, MG, Brasil
Abstract: Th17 cells have been associated with immune-mediated diseases in humans but it has still not been determined whether they play a role in immune thrombocytopenia. We evaluated representative cytokines of the Th17, Th1, Th2 and Treg cell commitment in the serum of patients with chronic immune thrombocytopenia, as well as the cell source of IL-17A. Higher levels of IL-17A and Th17-related cytokines, and an increased percentage of IL-17A producing CD4+ and neutrophils were observed in patients. The levels of cytokines involved in Th1 cell commitment IFN-γ, IL-2, IL12-p70 and the percentages of Th1 cells were also increased, but IL-4 was not detected. Although the concentrations of IL-10 were higher, the levels of TGF-b were similar in both groups. In conclusion, our results point to a putative role for Th-17 cells/IL-17A cytokine in the pathogenesis of chronic immune thrombocytopenia.
Keywords: immune thrombocytopenia
Th17 cell
Th1 cell
Th2 cell
Issue Date: 2011
Publisher: Ferrata Storti Foundation
Citation: ROCHA, Andreia Maria Camargos et al. The levels of IL-17A and of the cytokines involved in the Th17 cell commitment are increased in patients with chronic immune thrombocytopenia. Haematologica, v. 96, n. 10, p. 1560-1564, 2011.
DOI: 10.3324/haematol.2011.046417
ISSN: 0390-6078
Copyright: open access
Appears in Collections:IRR - Artigos de Periódicos



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