Author | Soares, Milena Botelho Pereira | |
Author | Costa, José Fernando Oliveira | |
Author | Sá, Matheus Santos de | |
Author | Santos, Ricardo Ribeiro dos | |
Author | Pigeon, Pascal | |
Author | Jaouen, Gérard | |
Author | Santana, Antônio Euzébio Goulart | |
Author | Goulart, Marilia Oliveira Fonseca | |
Author | Hillard, Elizabeth | |
Access date | 2014-12-02T12:46:58Z | |
Available date | 2014-12-02T12:46:58Z | |
Document date | 2010 | |
Citation | SOARES, M. B. P. et al. Antiparasitic and immunomodulatory activities of 1,1-bis(4-Hydroxyphenyl)-2-Phenyl-but-1-ene and Its protected and free 2-Ferrocenyl derivatives. Drug Development Research, v. 71, p. 69–75, 2010. | pt_BR |
ISSN | 0272-4391 | |
URI | https://www.arca.fiocruz.br/handle/icict/9025 | |
Language | eng | pt_BR |
Publisher | Wiley-Liss, INC | pt_BR |
Rights | open access | pt_BR |
Title | Antiparasitic and immunomodulatory activities of 1,1-bis(4-Hydroxyphenyl)-2-Phenyl-but-1-ene and Its protected and free 2-Ferrocenyl derivatives | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/ddr.20349 | |
Abstract | The ferrocenyl diphenol 1 [1,1-bis(4-hydroxyphenyl)-2-ferrocenyl-but-1-ene] displays
strong cytotoxic effects against a variety of cancer cells. In the present study we have evaluated the
immunomodulatory and antiparasitic activities of compound 1 and its protected dipalmitate analogue 2.
We have furthermore compared the antiparasitic results of 1 and 2 with the organic analogue, 3 [1,1-bis(4-
hydroxyphenyl)-2-phenyl-but-1-ene], where the ferrocenyl group has been replaced by a phenyl ring.
When assayed against normal (noncancerous) splenocytes, all compounds were considered nontoxic.
Compound 1 inhibited NO production by macrophages, inhibited concanavalin A-induced lymphoproliferation,
and was active against Leishmania amazonensis and Trypanosoma cruzi. Compound 2 had
lower activity in all assays performed. Surprisingly, compounds 1 and 2 exhibited similar and significant
activity against Plasmodium falciparum, with IC50 values of 3.50 and 1.33 mM, respectively. Compound 3
showed an inverse activity profile, being active against T. cruzi but far less active against P. falciparum. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | École Nationale Supérieure de Chimie de Paris. Laboratoire Charles Friedel. Paris, France | pt_BR |
Affilliation | École Nationale Supérieure de Chimie de Paris. Laboratoire Charles Friedel. Paris, France | pt_BR |
Affilliation | Instituto de Química e Biotecnologia. UFAL. Maceió, Al, Brasil | pt_BR |
Affilliation | Instituto de Química e Biotecnologia. UFAL. Maceió, Al, Brasil | pt_BR |
Affilliation | École Nationale Supérieure de Chimie de Paris. Laboratoire Charles Friedel. Paris, France | pt_BR |
Subject | Ferrocene | pt_BR |
Subject | Malaria | pt_BR |
Subject | Bioorganometallic chemistry | pt_BR |
Subject | Immunomodulatory | pt_BR |
Subject | Nitric oxide | pt_BR |
Subject | Chagas disease | pt_BR |