Author | Moreira, Diogo Rodrigo Magalhães | |
Author | Leite, Ana Cristina Lima | |
Author | Santos, Ricardo Ribeiro dos | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2014-11-28T14:21:07Z | |
Available date | 2014-11-28T14:21:07Z | |
Document date | 2009 | |
Citation | MOREIRA, D. R. M. et al. Approaches for the development of new anti-Trypanosoma cruzi agents. Current Drug Targets, v. 10, n. 3, p. 212-231, 2009 | pt_BR |
ISSN | 1873-5592 | |
URI | https://www.arca.fiocruz.br/handle/icict/9002 | |
Language | eng | pt_BR |
Publisher | Bentham Science Publishers Ltd | pt_BR |
Rights | open access | pt_BR |
Title | Approaches for the development of new anti-Trypanosoma cruzi agents | pt_BR |
Type | Article | pt_BR |
Abstract | The recent highlights on the biochemical pathways of Trypanosoma cruzi have allowed a significant improvement
in the development of new strategies for drug design and also in the understanding of the mechanisms of action of
new trypanocidal agents. Several biochemical pathways of fundamental importance and validated targets (e.g. cysteine
protease cruzain, trypanothione reductase, trans-sialidase) of T. cruzi have proved usefulness for drug development in
many examples of new candidates to anti-T. cruzi drugs. This review will focus on some approaches used for the design of
new potential trypanocidal agents, exploring modern concepts of medicinal chemistry such as bioisosterism, molecular
hybridization, bioinspired design in lead compounds, as well as the complexation of transition metals with bioactive
ligands. The examples discussed in this article may serve as lessons for the antitrypanosomal drug design | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Laboratório de Planejamento, Avaliação e Síntese de Fármacos. Departamento de Ciências Farmacêuticas, Recife, PE, Brasil | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Laboratório de Planejamento, Avaliação e Síntese de Fármacos. Departamento de Ciências Farmacêuticas, Recife, PE, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Av. São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Av. São Rafael. Salvador, BA, Brasil | pt_BR |
Subject | Chagas' disease | pt_BR |
Subject | Chemotherapy | pt_BR |
Subject | Rational drug design | pt_BR |
Subject | Medicinal chemistry | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
DeCS | Doença de Chagas/quimioterapia | pt_BR |
DeCS | Tripanossomicidas/farmacologia | pt_BR |
DeCS | Trypanosoma cruzi/efeitos de drogas | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Doença de Chagas/parasitologia | pt_BR |
DeCS | Sistemas de Liberação de Medicamentos | pt_BR |
DeCS | Desenho de Drogas | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Ligantes | pt_BR |
DeCS | Tripanossomicidas/uso terapêutico | pt_BR |