Author | Mello, Leonardo Araújo | |
Author | Figueiredo, Andreia Leal | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Gurgel, Clarissa Araújo Silva | |
Author | Martins, Manoela Domingues | |
Author | Figueiredo, Claudia Roberta Leite Vieira de | |
Author | Cury, Patrícia Ramos | |
Author | Albuquerque Junior, Ricardo Luiz Cavalcanti de | |
Author | Ramalho, Luciana Maria Pedreira | |
Author | Santos, Jean Nunes dos | |
Access date | 2014-11-19T16:39:30Z | |
Available date | 2014-11-19T16:39:30Z | |
Document date | 2013 | |
Citation | MELO, L. A. et al. CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 42, n. 6, p. 454-461, 2013. | pt_BR |
ISSN | 1600-0714 | |
URI | https://www.arca.fiocruz.br/handle/icict/8916 | |
Language | eng | pt_BR |
Publisher | John Wiley & Sons Ltd | pt_BR |
Rights | open access | pt_BR |
Title | CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/jop.12033 | |
Abstract | BACKGROUND: Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. OBJECTIVE AND METHODS: The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT). RESULTS: The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann-Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann-Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test). CONCLUSION: A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors. | pt_BR |
Affilliation | Federal University of Bahia | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Rio Grande do Sul. School of Dentistry. Departament of Oral Pathology. Porto Alegre, RS, Brasil | pt_BR |
Affilliation | Federal University of Paraíba. Department of General Pathology. João Pessoa, PB, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, Brasil | pt_BR |
Affilliation | Laboratory of Morphology and Structural Biology. Aracaju, SE, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Stomatology. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia | pt_BR |
Subject | Dendritic cell | pt_BR |
Subject | E-cadherin | pt_BR |
Subject | Langerhans cell | pt_BR |
Subject | Odontogenic tumors | pt_BR |
DeCS | Ameloblastoma/patologia | pt_BR |
DeCS | Antígenos CD1/análise | pt_BR |
DeCS | Caderinas/análise | pt_BR |
DeCS | Células de Langerhans/patologia | pt_BR |
DeCS | Tumores Odontogênicos/patologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso de 80 Anos ou mais | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Adesão Celular/fisiologia | pt_BR |
DeCS | Contagem de Células | pt_BR |
DeCS | Forma Celular | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Células Dendríticas/patologia | pt_BR |
DeCS | Células Epiteliais/patologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Queratinócitos/patologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Neoplasias Mandibulares/patologia | pt_BR |
DeCS | Cisto Odontogênico Calcificante/patologia | pt_BR |