Author | Lima, Milena da Silva | |
Author | Quintans Junior, Lucindo José | |
Author | Santana, Wagno Alcântara | |
Author | Kaneto, Carla Martins | |
Author | Soares, Milena Botelho Pereira | |
Author | Villarreal, Cristiane Flora | |
Access date | 2014-10-08T18:03:30Z | |
Available date | 2014-10-08T18:03:30Z | |
Document date | 2013 | |
Citation | LIMA, M. S. et al. Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10. European Journal of Pharmacology, v. 699, n. 1-3, p. 112-117, 2013. | pt_BR |
ISSN | 1879-0712 | |
URI | https://www.arca.fiocruz.br/handle/icict/8552 | |
Language | eng | pt_BR |
Publisher | Elsevier B.V | pt_BR |
Rights | open access | pt_BR |
Title | Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ejphar.2012.11.040 | |
Abstract | Carvacrol,aphenolicmonoterpene,hasbeenreportedtopossessanti-inflammatoryproperties.
However,themechanismsinvolvedinitspharmacologicalpropertiesarecurrentlynotwellunder-
stood. Inthepresentstudy,thecontributionofcytokinemodulationtotheanti-inflammatoryeffectsof
carvacrolwasinvestigatedinaclassicalinflammationmodel:thecompleteFreund’sadjuvant(CFA)-
inducedpawinflammationinmice.Thepawedemawasmeasuredusingaplesthismometer.Pawtissue
was removed2haftertheinflammatorystimulustodeterminethelevelsofprostaglandinE2 (PGE2) by
enzyme immunoassay,thelevelsofinterleukin-1 b (IL-1b), tumornecrosisfactor-a (TNF-a), and
interleukin-10(IL-10)byELISAorthemRNAexpressionofcyclooxygenase-2(COX-2),IL-1b, TNF-a, and
IL-10 byreal-timePCR.Administrationofcarvacrolproducedanti-inflammatoryeffectsagainstCFA-
inducedinflammationinmice.Treatmentofmicewithcarvacrolat50and100mg/kgattenuatedthe
paw edemaandreducedtheIL-1b and PGE2, butnotTNF-a, locallevels.Similarly,carvacrol(100mg/kg)
reducedtheCOX-2andIL-1b mRNA expression.ThelevelsofIL-10,ananti-inflammatorycytokine,and
the IL-10mRNAexpressionintheinflamedpawwereenhancedbycarvacrol.Inaddition,thetreatment
with carvacroldidnotreducetheCFA-inducedpawedemainIL-10knockoutmice.Thepresentresults
suggestthatcarvacrolcausesanti-inflammatoryeffectsbyreducingtheproductionofinflammatory
mediators,suchasIL-1b and prostanoids,possiblythroughtheinductionofIL-10release. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, Brasil | pt_BR |
Affilliation | Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Carvacrol | pt_BR |
Subject | Anti-inflammatory | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Interleukin-10 | pt_BR |
Subject | PGE2 | pt_BR |
DeCS | Anti-Inflamatórios/farmacologia | pt_BR |
DeCS | Inflamação/quimioterapia | pt_BR |
DeCS | Interleucina-10/metabolismo | pt_BR |
DeCS | Monoterpenos/farmacologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Anti-Inflamatórios/administração & dosagem | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Relação Dose-Resposta a Droga | pt_BR |
DeCS | Edema/quimioterapia | pt_BR |
DeCS | Regulação da Expressão Gênica/efeitos de drogas | pt_BR |
DeCS | Mediadores da Inflamação/metabolismo | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos C57BL | pt_BR |
DeCS | Monoterpenos/administração & dosagem | pt_BR |
DeCS | Reação em Cadeia da Polimerase em Tempo Real | pt_BR |