Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/8496
CANDIDA SPECIES ISOLATED FROM THE VAGINAL MUCOSA OF HIV-INFECTED WOMEN IN SALVADOR, BAHIA, BRAZIL.
Candida/isolamento & purificação
Candidíase Vulvovaginal/microbiologia
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico
Adulto
Antifúngicos/farmacologia
Brasil
Candida/classificação
Candida/efeitos de drogas
Candidíase Vulvovaginal/diagnóstico
Feminino
Humanos
Testes de Sensibilidade Microbiana
Membrana Mucosa/microbiologia
Prevalência
Vagina/microbiologia
Author
Affilliation
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Laboratoire de Mycologie-Parasitologie. Paris, France
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançadao de Saúde Pública. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Laboratoire de Mycologie-Parasitologie. Paris, France
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançadao de Saúde Pública. Salvador, BA, Brasil
Abstract
Background: Vulvovaginal candidiasis (VVC) is the second most common vaginal infection.
HIV-infection is a risk factor for this infection. Objective: To determine the frequency
of VVC and to describe the main Candida species isolated and their susceptibility to antifungal
drugs in HIV-infected patients, compared to HIV-uninfected women in Salvador, Brazil.
Methods: Cross-sectional study including a group of 64 HIV-infected women and 76 uninfected
women, followed up at the AIDS reference center and at the Gynecological Clinic of Escola
Bahiana de Medicina e Saúde Pública (Salvador, Bahia, Brazil). Results: Frequency of Candida spp.
was higher in HIV-infected women (29.7%) than in HIV-uninfected controls (14.5%) (p = 0.02).
The odds ratio value for vulvovaginal candidiasis in HIV-infected patients was 2.6 (95% CI:
1.07 - 6.32 p = 0.03). Candida albicans was the most commonly isolated species in both HIV-infected
(52.3%) and uninfected women (85.7%), followed by C. parapsolis in 17.6% and 14.3%, respectively.
In HIV-infected women, C. glabrata, C. parapsilosis, and a coinfection of C. albicans and
C. glabrata were also identified. There was no significant difference between Candida species
isolated from the vaginal mucosa of women with VVC and colonization of the vaginal mucosa
of HIV-infected and HIV-uninfected women. One C. glabrata isolate from an HIV-infected patient
was resistant to fluconazole and other two isolates exhibited a dose-dependent susceptibility.
Conclusion: Our results confirm a higher frequency of Candida spp. isolated from the vaginal mucosa
of HIV-infected women and a broader spectrum of species involved. Only Candida glabrata
isolates showed decreased susceptibility to fluconazole.
DeCS
Infecções Oportunistas Relacionadas com a AIDS/microbiologiaCandida/isolamento & purificação
Candidíase Vulvovaginal/microbiologia
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico
Adulto
Antifúngicos/farmacologia
Brasil
Candida/classificação
Candida/efeitos de drogas
Candidíase Vulvovaginal/diagnóstico
Feminino
Humanos
Testes de Sensibilidade Microbiana
Membrana Mucosa/microbiologia
Prevalência
Vagina/microbiologia
Share