Author | Barbosa, Marília Imaculada Frazão | |
Author | Corrêa, Rodrigo de Souza | |
Author | Oliveira, Katia Mara de | |
Author | Rodrigues, Claudia | |
Author | Ellena, Javier Alcides | |
Author | Nascimento, Otaciro Rangel | |
Author | Rocha, Vinícius Pinto Costa | |
Author | Nonato, Fabiana Regina | |
Author | Macedo, Taís Soares | |
Author | Barbosa Filho, José Maria | |
Author | Soares, Milena Botelho Pereira | |
Author | Batista, Alzir Azevedo | |
Access date | 2014-09-26T19:24:26Z | |
Available date | 2014-09-26T19:24:26Z | |
Document date | 2014 | |
Citation | BARBOSA, M. I. F. et al. Antiparasitic activities of novel ruthenium/lapachol complexes. Journal of Inorganic Biochemistry, v. 136, p. 33-39, 2014. | pt_BR |
ISSN | 1873-3344 | |
URI | https://www.arca.fiocruz.br/handle/icict/8462 | |
Language | eng | pt_BR |
Publisher | Elsevier Inc | pt_BR |
Rights | open access | pt_BR |
Title | Antiparasitic activities of novel ruthenium/lapachol complexes. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jinorgbio.2014.03.009 | |
Abstract | The present study describes the synthesis, characterization, antileishmanial and antiplasmodial activities of novel diimine/(2,2'-bipyridine (bipy), 1,10-phenanthroline (phen), 4,4'-methylbipyridine (Me-bipy) and 4,4'-methoxybipyridine (MeO-bipy)/phosphine/ruthenium(II) complexes containing lapachol (Lap, 2-hydroxy-3-(3-33 methyl-2-buthenyl)-1,4-naphthoquinone) as bidentate ligand. The [Ru(Lap)(PPh3)2(bipy)]PF6 (1), [Ru(Lap)(PPh3)2(Me-bipy)]PF6 (2), [Ru(Lap)(PPh3)2(MeO-bipy)]PF6(3) and[Ru(Lap)(PPh3)2(phen)]PF6 (4) complexes, PPh3=triphenylphospine, were synthesized from the reactions of cis-[RuCl2(PPh3)2(X-bipy)] or cis-[RuCl2(PPh3)2(phen)], with lapachol. The [RuCl2(Lap)(dppb)] (5) [dppb=1,4-bis(diphenylphosphine)butane] was synthesized from the mer-[RuCl3(dppb)(H2O)] complex. The complexes were characterized by elemental analysis, molar conductivity, infrared and UV-vis spectroscopy, (31)P{(1)H} and (1)H NMR, and cyclic voltammetry. The Ru(III) complex, [RuCl2(Lap)(dppb)], was also characterized by the EPR technique. The structure of the complexes [Ru(Lap)(PPh3)2(bipy)]PF6 and [RuCl2(Lap)(dppb)] was elucidated by X-ray diffraction. The evaluation of the antiparasitic activities of the complexes against Leishmania amazonensis and Plasmodium falciparum demonstrated that lapachol-ruthenium complexes are more potent than the free lapachol. The [RuCl2(Lap)(dppb)] complex is the most potent and selective antiparasitic compound among the five new ruthenium complexes studied in this work, exhibiting an activity comparable to the reference drugs. | pt_BR |
Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil | pt_BR |
Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil | pt_BR |
Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil | pt_BR |
Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil | pt_BR |
Affilliation | Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil | pt_BR |
Subject | Ruthenium (II) and (III) lapachol complex | pt_BR |
Subject | Cytotoxicity | pt_BR |
Subject | Antileishmanial and antiplasmodial activities | pt_BR |