Author | Dekrey, Gregory K | |
Author | Jones, Jeremy J | |
Author | Mbow, M. Lamine | |
Author | Brodskyn, Claudia Ida | |
Author | Titus, Richard G | |
Access date | 2014-09-19T12:48:28Z | |
Available date | 2014-09-19T12:48:28Z | |
Document date | 2003 | |
Citation | DEKREY, G. K. et al. Short report: requirement of b cells for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57BL/6 mice. American Journal of Tropical Medicine and Hygiene, v. 69, n. 5, p. 481-483, 2003. | pt_BR |
ISSN | 0002-9637 | |
URI | https://www.arca.fiocruz.br/handle/icict/8401 | |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | |
Title | Short report: requirement of b cells for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57BL/6 mice | pt_BR |
Type | Article | pt_BR |
Abstract | B cell-deficient C57Bl/6 ( MT) mice were resistant to Leishmania major after both primary and secondary
parasite challenge. However, unlike in wild-type mice, secondary infection in MT mice was not accompanied by a
marked delayed type hypersensitivity-like response, and interferon- (IFN- ) levels were approximately half of those in
wild-type mice. These results suggest that B cells are involved in IFN- production and the pathology of secondary
infection. | pt_BR |
Affilliation | University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado | pt_BR |
Affilliation | Colorado State University. Department of Pathology. Fort Collins, Colorado | pt_BR |
Affilliation | Centocor, Incorporated, Infectious Diseases. Malvern, Pennsylvania | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Colorado State University. Department of Pathology. Fort Collins, Colorado | pt_BR |
DeCS | Linfócitos B/imunologia | pt_BR |
DeCS | Hipersensibilidade Tardia/patologia | pt_BR |
DeCS | Leishmania major/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Interferon gama/biossíntese | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos C57BL | pt_BR |
DeCS | Camundongos Knockout | pt_BR |