Author | Rios, Domingos Lázaro Souza | |
Author | D’Onofrio, Lorenza O | |
Author | Cerqueira, Caio Cesar Silva | |
Author | Silva, Ricardo Bonfim | |
Author | Carvalho, Heitor Ghissoni de | |
Author | Santos Filho, Ademar | |
Author | Castro Filho, Bernardo Galvão | |
Access date | 2014-08-22T17:15:19Z | |
Available date | 2014-08-22T17:15:19Z | |
Document date | 2007 | |
Citation | RIOS, D. L. S. et al. Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians. Clinical Chemistry and Laboratory Medicine, v. 45, n. 7, p. 874-878, 2007. | pt_BR |
ISSN | 1434-6621 | |
URI | https://www.arca.fiocruz.br/handle/icict/8220 | |
Language | eng | pt_BR |
Publisher | Walter de Gruyter | pt_BR |
Rights | open access | pt_BR |
Title | Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians. | pt_BR |
Type | Article | pt_BR |
Abstract | BACKGROUND: Paraoxonases (PON) are members of an enzyme family involved in preventing low-density lipoprotein oxidation and therefore protecting against atherosclerotic plaque formation. METHODS: We studied the Met55Leu and Gln192Arg PON1 polymorphisms in 712 patients (437 Caucasian- and 275 African-Brazilians) who underwent coronary angiography. RESULTS: Among Caucasian-Brazilians, the homozygous 55LeuLeu frequency was higher among patients with significant coronary artery disease (CAD, obstructive lesions >/=50%) than among lesion-free controls (51% vs. 30.3%; p=0.022) in females, but not in males. The Gln192Arg PON1 polymorphism was not associated with CAD, although 192GlnGln homozygotes presented lower high-density lipoprotein (HDL)-cholesterol (p=0.035) and higher triglyceride (p=0.012) levels than 192Arg allele carriers among Caucasian-Brazilian males, but not females. No other lipid-genotype association was detected. Multivariate logistic regression corrected for classic CAD risk factors shows that 55LeuLeu PON1 homozygotes were at increased CAD risk (odds ratio OR=2.852; p=0.003) and that this genotype interacted with gender in its association with CAD risk (OR=0.290; p=0.006) among Caucasian-Brazilians. CONCLUSIONS: This report shows that the 55LeuLeu PON1 genotype increases CAD risk among female Caucasian-Brazilians, irrespective of other CAD risk factors. In addition, 192GlnGln PON1 homozygotes show higher triglyceride and lower HDL-cholesterol levels in male Caucasian-Brazilians. No associations were detected among African-Brazilians. | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Laboratório de Genética Molecular. Jequié, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Laboratório de Genética Molecular. Jequié, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Laboratório de Genética Molecular. Jequié, BA, Brasil | pt_BR |
Affilliation | Hospital Santa Izabel. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Santa Izabel. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Subject | African-Brazilians | pt_BR |
Subject | Coronary artery disease | pt_BR |
Subject | Paraoxonase | pt_BR |
Subject | Polymorphism | pt_BR |
DeCS | Arildialquilfosfatase/genética | pt_BR |
DeCS | Doença da Artéria Coronariana/genética | pt_BR |
DeCS | Polimorfismo Genético | pt_BR |
DeCS | Alelos | pt_BR |
DeCS | Arildialquilfosfatase/metabolismo | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | HDL-Colesterol/metabolismo | pt_BR |
DeCS | Angiografia Coronária | pt_BR |
DeCS | Doença da Artéria Coronariana/enzimologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Predisposição Genética para Doença | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Fatores de Risco | pt_BR |
DeCS | Triglicerídeos/metabolismo | pt_BR |