Author | Nogueira, Renata Campos | |
Author | Rocha, Vinícius Pinto Costa | |
Author | Nonato, Fabiana Regina | |
Author | Tomassini, Therezinha Coelho Barbosa | |
Author | Ribeiro, Ivone Maria | |
Author | Santos, Ricardo Ribeiro dos | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2014-08-11T19:08:19Z | |
Available date | 2014-08-11T19:08:19Z | |
Document date | 2013 | |
Citation | NOGUEIRA, R. C. et al. Genotoxicity and antileishmanial activity evaluationof Physalisangulata concentrated ethanolic extract. Environmental Toxicology and Pharmacology, v. 36, n. 3, p.1304-1311, 2013. | pt_BR |
ISSN | 1382-6689 | |
ISSN | dx.doi.org/10.1016/j.etap.2013.10.013 | |
URI | https://www.arca.fiocruz.br/handle/icict/8185 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Title | Genotoxicity and antileishmanial activity evaluationof Physalisangulata concentrated ethanolic extract | pt_BR |
Type | Article | pt_BR |
Abstract | Antileishmanial in vitro tests, aswellasAmesandmicronucleusassayswereperformed
with aconcentratedethanolicextractof Physalisangulata (EEPA)
Results: EEPAdidnotpresentmutageniceffectin Salmonella typhimurium strainsatcon-
centrationreaching3000 g/plate anddidnotinducemutageniceffectsaftertwooral
administrationswitha24hintervalatadoselevelof2000mg/kg.EEPApresentedantileish-
manial activityandpresentedanIC50 valueof5.35±2.50 g/mL and4.50±1.17 g/mL
against Leishmania amazonensis and Leishmania braziliensis promastigotes,respectively.Inthe
cytotoxicitytestagainstmacrophages,theEEPAhadaLC50 of 6.14±0.59 g/mL. Importantly,
the IC50 against L. amazonensis intracellularamastigoteswas1.23±0.11 g/mL.
Conclusion: EEPAextractisnon-mutagenicandpresentedapromisingpharmacologicaleffect
against Leishmania parasites. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. FarManguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Genotoxicity | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Physalisangulata L. | pt_BR |
Subject | Ames test | pt_BR |
Subject | Micronucleustest | pt_BR |