Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/8128
Title: Increasing seroprevalence of human herpesvirus 8 (HHV-8) with age confirms HHV-8 endemicity in Amazon Amerindians from Brazil.
Authors: Cunha, Andréa Mendonça Gusmão
Araujo, Adele Caterino de
Costa, Sandra Cecilia Botelho
Fortuna, Elisabeth Santos
Boa-Sorte, Ney Cristian Amaral
Gonçalves, Marilda de Souza
Costa, Fernando Ferreira
Castro Filho, Bernardo Galvão
Affilliation: School of Medical Sciences. Departments of Clinical Pathology and Internal Medicine. State University of Campinas. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Adolfo Lutz Institute. Immunology Section. São Paulo, SP, Brasil
School of Medical Sciences. Departments of Clinical Pathology and Internal Medicine. State University of Campinas. Campinas, SP, Brasil
Adolfo Lutz Institute. Immunology Section. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahiana Medical School. Bahiana Foundation for the Development of Sciences. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasi
School of Medical Sciences. Departments of Clinical Pathology and Internal Medicine. State University of Campinas. Campinas, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Bahiana Medical School. Bahiana Foundation for the Development of Sciences. Salvador, BA, Brasil
Abstract: Human herpesvirus 8 (HHV-8) seroprevalences were determined in two isolated Amazon Amerindian tribes, according to age, gender and familial aggregation. Plasma and serum samples obtained from 982 Amazon Amerindians (664 Tiriyo´ and 318 Waiampi) were tested for antibodies against lytic and latent HHV-8 antigens by using ‘in-house’ immunofluorescence assays. Overall, HHV-8 seroprevalence was 56?8% (57?4% in the Tiriyo´ tribe and 55?7% in the Waiampi tribe). Seroprevalence was independent of gender and increased linearly with age: it was 35?0% among children aged 2–9 years, 51?4% in adolescents (10–19 years), 72?9% in adults and 82?3% in adults aged >50 years. Interestingly, 44?4% of children under 2 years of age were HHV-8-seropositive. No significant differences in seroprevalence between tribes and age groups were detected. It is concluded that HHV-8 is hyperendemic in Brazilian Amazon Amerindians, with vertical and horizontal transmission during childhood, familial transmission and sexual contact in adulthood contributing to this high prevalence in these isolated populations.
DeCS: Anticorpos Antivirais/sangue
Doenças Endêmicas
Infecções por Herpesviridae/etnologia
Herpesvirus Humano 8/imunologia
Índios Sul-Americanos
Adolescente
Adulto
Distribuição por Idade
Antígenos Virais/imunologia
Brasil/epidemiologia
Criança
Pré-Escolar
Grupos Étnicos
Feminino
Infecções por Herpesviridae/virologia
Humanos
Lactente
Masculino
Meia-Idade
Estudos Soroepidemiológicos
Distribuição por Sexo
Issue Date: 2005
Publisher: Society for General Microbiology
Citation: CUNHA, A. M. G. et al. Increasing seroprevalence of human herpesvirus 8 (HHV-8) with age confirms HHV-8 endemicity in Amazon Amerindians from Brazil. Journal of General Virology, v. 86, pt 9, p. 2433-2437, 2005.
DOI: 10.1099/vir.0.81087-0
ISSN: 0022-1317
Copyright: open access
Appears in Collections:CPqGM - Artigos de Periódicos

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