Author | Mascarenhas, Rita Elizabeth Moreira | |
Author | Brodskyn, Claudia Ida | |
Author | Barbosa, Geisa | |
Author | Clarêncio, Jorge | |
Author | Andrade Filho, Antonio de Souza | |
Author | Figueiroa, Frederico | |
Author | Castro Filho, Bernardo Galvão | |
Author | Grassi, Maria Fernanda Rios | |
Access date | 2014-08-04T18:42:15Z | |
Available date | 2014-08-04T18:42:15Z | |
Document date | 2006 | |
Citation | MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006. | pt_BR |
ISSN | 1556-6811 | |
URI | https://www.arca.fiocruz.br/handle/icict/8125 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Title | Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/CVI.13.5.547–552.2006 | |
Abstract | Evidence indicates that human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to chronic
immunosuppression and a greater susceptibility to infectious diseases. Spontaneous in vitro proliferation of
peripheral blood mononuclear cells (PBMC) is an important immunological feature of HTLV-1-infected
individuals. However, the association between spontaneous proliferation and immunosuppression is not clear.
In this study, we evaluated the cellular immune responses of PBMC from 58 asymptomatic HTLV-1-infected
individuals with PBMC showing or not showing spontaneous proliferation. Individuals with PBMC that
spontaneously proliferated had increased proportions of CD4 T cells expressing CD45RO and dramatically
reduced responses to recall antigens. In addition, frequencies of positive responses to recall antigens were also
decreased in HTLV-infected individuals without spontaneous proliferation of PBMC. There was a polyclonal
expansion of multiple T-cell receptor V families of CD4 T lymphocytes in patients with spontaneous
proliferation. We observed that HTLV-1 induced an immunosuppression characterized by a decrease in the
stimulation index to a recall antigen, even in individuals who did not present spontaneous proliferation. On the
other hand, only patients with PBMC presenting spontaneous proliferation showed polyclonal activation and
increased proportion of CD4 T cells expressing CD45RO. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil | pt_BR |
Affilliation | Neurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Neurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
DeCS | Antígenos/imunologia | pt_BR |
DeCS | Infecções por HTLV-I/imunologia | pt_BR |
DeCS | Vírus 1 Linfotrópico T Humano/imunologia | pt_BR |
DeCS | Tolerância Imunológica/imunologia | pt_BR |
DeCS | Leucócitos Mononucleares/imunologia | pt_BR |
DeCS | Subpopulações de Linfócitos T/imunologia | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Antígenos CD45/biossíntese | pt_BR |
DeCS | Linfócitos T CD4-Positivos/citologia | pt_BR |
DeCS | Proliferação de Células | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Memória Imunológica | pt_BR |
DeCS | Leucócitos Mononucleares/citologia | pt_BR |
DeCS | Ativação Linfocitária | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Proteína Tirosina Fosfatase não Receptora Tipo 1 | pt_BR |
DeCS | Receptores de Antígenos de Linfócitos T/análise | pt_BR |