Author | Rios, Domingos Lázaro Souza | |
Author | D’Onofrio, Lorenza O | |
Author | Souza, Joares Kelton de Oliveira | |
Author | Queiroz, Amália M | |
Author | Maron, Luciana Raduy | |
Author | Silva Neto, Naila | |
Author | Carvalho, Heitor Ghissoni de | |
Author | Santos Filho, Ademar | |
Author | Castro Filho, Bernardo Galvão | |
Access date | 2014-08-01T19:43:07Z | |
Available date | 2014-08-01T19:43:07Z | |
Document date | 2006 | |
Citation | RIOS, D. L. S. et al. Smoking-dependent and haplotype-specific effects of endothelial nitric oxide synthase gene polymorphisms on angiographically assessed coronary artery disease in Caucasian- and African-Brazilians. Atherosclerosis, v. 193, n. 1, p. 135–141, 2007. | pt_BR |
ISSN | 0021-9150 | |
URI | https://www.arca.fiocruz.br/handle/icict/8119 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Smoking-dependent and haplotype-specific effects of endothelial nitric oxide synthase gene polymorphisms on angiographically assessed coronary artery disease in Caucasian- and African-Brazilians. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.atherosclerosis.2006.05.041 | |
Abstract | The nitric oxide produced by endothelial nitric oxide synthase (eNOS) plays a pivotal role in protecting the arterial wall from damages
and atherosclerosis. The T–786C, the 27-bp repeat in intron 4, and the E298D eNOS gene polymorphisms were studied in 715 Brazilian
patients (447 Caucasian- and 268 African-Brazilians) who underwent coronary angiography. The −786C frequency was increased in coronary
artery disease (CAD) cases with significant lesions (≥50% luminal obstruction) when compared with lesion-free controls; this difference was
detected in smokers but not in nonsmokers, both in Caucasian- (p = 0.011) and African-Brazilians (p = 0.005). The interaction between−786C
carriers and smoking was an independent CAD predictor (OR: 2.9, 95% CI: 1.4–5.9; p = 0.003) in multiple logistic regression. The 298D
mutation frequency was also higher among CAD cases (p = 0.036) in African-Brazilian smokers, but this effect was not independent from
other variables in the regression model. Though not associated with CAD, the 4-repeat allele combined with different T–786C alleles showed
protective and susceptible effects in Caucasian-Brazilian smokers. The −786C/4-repeat/298E haplotype frequency was higher (p = 0.020),
whereas −786T/4-repeat/298E was lower (p = 0.023) in these cases. These results showed a smoking-dependent effect of the T–786C eNOS
polymorphism on CAD in both Caucasian- and African-Brazilians. Additionally, the haplotype analysis revealed different eNOS haplotypes
associated with protection and susceptibility to the disease. | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. UESB. Laboratório de Genética Molecular. Departamento de Ciências Biológicas. Jequié, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Santa Izabel. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Santa Izabel. Salvador, BA, | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Salvador, BA, Brasil | pt_BR |
Subject | Coronary artery disease | pt_BR |
Subject | Endothelial nitric oxide synthase | pt_BR |
Subject | Polymorphisms | pt_BR |
Subject | African-Brazilians | pt_BR |
Subject | Grupo com Ancestrais do Continente Africano/genética | pt_BR |
Subject | Alelos | pt_BR |
DeCS | Doença da Artéria Coronariana/enzimologia | pt_BR |
DeCS | Óxido Nítrico Sintase Tipo III/genética | pt_BR |
DeCS | Polimorfismo Genético | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Estudos de Casos e Controles | pt_BR |
DeCS | Angiografia Coronária | pt_BR |
DeCS | Doença da Artéria Coronariana/etiologia | pt_BR |
DeCS | Grupo com Ancestrais do Continente Europeu/genética | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Frequência do Gene | pt_BR |
DeCS | Haplotipos | pt_BR |
DeCS | Heterozigoto | pt_BR |
DeCS | Homozigoto | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Íntrons | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Sequências Repetitivas do Ácido Nucleico | pt_BR |
DeCS | Hábito de Fumar/efeitos adversos | pt_BR |