Author | Lins, Liliane | |
Author | Carvalho, Victor José Uchoa de | |
Author | Rego, Filipe Ferreira de Almeida | |
Author | Azevedo, Rochele | |
Author | Kashima, Simone G | |
Author | Gallazzi, Viviana Nilla Olavarria | |
Author | Xavier, Marcia Tosta | |
Author | Castro Filho, Bernardo Galvão | |
Author | Alcantara, Luiz Carlos Júnior | |
Access date | 2014-07-24T17:49:45Z | |
Available date | 2014-07-24T17:49:45Z | |
Document date | 2012 | |
Citation | LINS, L. et al. Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva. Journal of Medical Virology, v. 84, n. 9, p. 1428-1436, 2012. | pt_BR |
ISSN | 1096-9071 | |
URI | https://www.arca.fiocruz.br/handle/icict/8076 | |
Language | eng | pt_BR |
Publisher | Wiley Online Library | pt_BR |
Rights | open access | pt_BR |
Title | Oral health profile in patients infected with HTLV-1: clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/jmv.23327 | |
Abstract | Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been implicated in several disorders, including periodontal disease. The proviral load is an important biological marker for understanding HTLV-1 pathogenesis and elucidating whether or not the virus is related to the clinical manifestation of the disease. This study describes the oral health profile of HTLV-1 carriers and HAM/TSP patients in order to investigate the association between the proviral load in saliva and the severity of the periodontal disease and to examine virus intra-host variations from peripheral blood mononuclear cells and saliva cells. It is a cross-sectional analytical study of 90 individuals carried out from November 2006 to May 2008. Of the patients, 60 were HTLV-1 positive and 30 were negative. Individuals from the HTLV-1 positive and negative groups had similar mean age and social-economic status. Data were analyzed using two available statistical software packages, STATA 8.0 and SPSS 11.0 to conduct frequency analysis. Differences of P < 0.05 were considered statistically significant. HTLV-1 patients had poorer oral health status when compared to seronegative individuals. A weak positive correlation between blood and saliva proviral loads was observed. The mean values of proviral load in blood and saliva in patients with HAM/TSP was greater than those in HTLV-1 carriers. The HTLV-1 molecular analysis from PBMC and saliva specimens suggests that HTLV-1 in saliva is due to lymphocyte infiltration from peripheral blood. A direct relationship between the proviral load in saliva and oral manifestations was observed. | pt_BR |
Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Salvador, BA, Brasil | pt_BR |
Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | National Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, Brasil | pt_BR |
Affilliation | National Institute of Science and Technology in Stem Cells and Cell Theraphy University of São Paulo. USP School of Medicine. Ribeirao Preto, SP, Brasil | pt_BR |
Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Bahiana School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Oral health | pt_BR |
Subject | Saliva | pt_BR |
Subject | HTLV-1 | pt_BR |
DeCS | Portador Sadio/virologia | pt_BR |
DeCS | Vírus 1 Linfotrópico T Humano/genética | pt_BR |
DeCS | Paraparesia Espástica Tropical/virologia | pt_BR |
DeCS | Provirus/genética | pt_BR |
DeCS | Saliva/virologia | pt_BR |
DeCS | Carga Viral | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Estudos Transversais | pt_BR |
DeCS | DNA Viral/genética | pt_BR |
DeCS | Dieta Cariogênica | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Leucócitos Mononucleares/virologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Doenças Periodontais/virologia | pt_BR |
DeCS | Salivação | pt_BR |
DeCS | Análise de Sequência de DNA | pt_BR |
DeCS | Adulto Jovem | pt_BR |