Author | Dantas, Marina Loyola | |
Author | Oliveira, Juliana Cabral de | |
Author | Carvalho, Lucas Pedreira de | |
Author | Passos, Sara Timóteo | |
Author | Queiroz, Adriano | |
Author | Machado, Paulo Roberto | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Arruda, Sérgio Marcos | |
Access date | 2014-06-04T12:35:44Z | |
Available date | 2014-06-04T12:35:44Z | |
Document date | 2013 | |
Citation | DANTAS, M. L. et al. CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 46, n. 6, p. 728-734, 2013. | pt_BR |
ISSN | 1678-9849 | |
URI | https://www.arca.fiocruz.br/handle/icict/7788 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
Rights | open access | pt_BR |
Title | CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis. | pt_BR |
Type | Article | pt_BR |
DOI | dx.doi.org/10.1590/0037-8682-0174-2013 | |
Abstract | Introduction: Leishmania braziliensis infection induces a large spectrum of lesions that clinically manifest as nodules or papules
that progress to ulcers. Although it is already known that T helper cells predominate in the lesions, cytotoxic T cells have also
been reported to be present, and their role in leishmaniasis immunopathogenesis is not well known. This study investigated
the amounts of CD8+ and granzyme B+ cells in different clinical forms of human cutaneous leishmaniasis (CL). Methods:
Forty tissue fragments from early (E-CL) and late CL (L-CL) lesions and from disseminated leishmaniasis (DL) - papules and
ulcers - were characterized. The infl amed area per fragment was calculated, and the CD8 and granzyme B expression levels
in the infi ltrates were quantifi ed by counting positive cells in 15 fi elds. The localization of CD8 and granzyme B was graded
subjectively. Results: Infl ammation was higher in L-CL and DL ulcers. CD8 expression was increased in late ulcerated lesions
compared to recent lesions. The increase in CD8+ cells also correlated with the duration of the lesion. Papules had a higher
frequency of granzyme B+ cells than E-CL lesions, although the frequency was similar to those for late and DL ulcers. CD8+
cells were mostly found in the papillary dermis. Conclusions: CD8+ T and granzyme B+ cells are present in the infl ammatory
infi ltrates of CL and DL and may participate in the immunopathogenesis of Leishmania infection. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Cytotoxicity | pt_BR |
Subject | Infl ammation | pt_BR |
Subject | Cutaneous. | pt_BR |
Subject | CD8 | pt_BR |
Subject | Human | pt_BR |
Subject | Linfócitos T CD8-Positivos/enzimologia | pt_BR |
DeCS | Linfócitos T CD8-Positivos/imunologia | pt_BR |
DeCS | Granzimas/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Leishmaniose Cutânea/patologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Adulto Jovem | pt_BR |