Author | Giusta, Caroline Junqueira | |
Author | Guerrero, Ana Tereza | |
Author | Galvão Filho, Bruno | |
Author | Andrade, Warrison Athanásio Coelho de | |
Author | Salgado, Ana Paula Carneiro | |
Author | Cunha, Thiago Mattar | |
Author | Ropert, Catherine | |
Author | Campos, Marco Antônio da Silva | |
Author | Penido, Marcus Luiz de Oliveira | |
Author | Previato, Lúcia Mendonça | |
Author | Previato, Jose Oswaldo | |
Author | Ritter, Gerd | |
Author | Cunha, Fernando Queiroz | |
Author | Gazzinelli, Ricardo Tostes | |
Access date | 2014-05-14T16:09:13Z | |
Available date | 2014-05-14T16:09:13Z | |
Document date | 2012 | |
Citation | JUNQUEIRA, Caroline et al. Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine. Plos One. 2012, vol.7, pp. e36245 | pt_BR |
ISSN | 1932-6203 | |
URI | https://www.arca.fiocruz.br/handle/icict/7626 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Trypanosoma cruzi adjuvants potentiate T Cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0036245 | |
Abstract | Immunological adjuvants that induce T cell-mediate immunity (TCMI) with the least side effects are needed for the development of human vaccines. Glycoinositolphospholipids (GIPL) and CpGs oligodeoxynucleotides (CpG ODNs) derived from the protozoa parasite Trypanosoma cruzi induce potent pro-inflammatory reaction through activation of Toll-Like Receptor (TLR) 4 and TLR9, respectively. Here, using mouse models, we tested the T. cruzi derived TLR agonists as immunological adjuvants in an antitumor vaccine. For comparison, we used well-established TLR agonists, such as the bacterial derived monophosphoryl lipid A (MPL), lipopeptide (Pam3Cys), and CpG ODN. All tested TLR agonists were comparable to induce antibody responses, whereas significant differences were noticed in their ability to elicit CD4(+) T and CD8(+) T cell responses. In particular, both GIPLs (GTH, and GY) and CpG ODNs (B344, B297 and B128) derived from T. cruzi elicited interferon-gamma (IFN-gamma) production by CD4(+) T cells. On the other hand, the parasite derived CpG ODNs, but not GIPLs, elicited a potent IFN-gamma response by CD8(+) T lymphocytes. The side effects were also evaluated by local pain (hypernociception). The intensity of hypernociception induced by vaccination was alleviated by administration of an analgesic drug without affecting protective immunity. Finally, the level of protective immunity against the NY-ESO-1 expressing melanoma was associated with the magnitude of both CD4+ T and CD8+ T cell responses elicited by a specific immunological adjuvant. | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Instituto Cerrado Pantanal. Campo Grande, MT, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil, | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts. Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, United States of America | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Instituto de Biofısica Carlos Chagas Filho. Centro de Ciencias da Saude. Universidade Federal do Rio de Janeiro. Rio de Janeiro, Brazil | pt_BR |
Affilliation | Instituto de Biofısica Carlos Chagas Filho. Centro de Ciencias da Saude. Universidade Federal do Rio de Janeiro. Rio de Janeiro, Brazil | pt_BR |
Affilliation | New York Branch at Memorial Sloan–Kettering Cancer Center.Ludwig Institute for Cancer Research. New York, New York, United States of America | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Farmacologia. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte,MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts. Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, United States of America | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | immunology | pt_BR |