Author | Pompeu, Margarida Maria de Lima | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Santos, M. L. V | |
Author | Khouri, M | |
Author | Barral Netto, Manoel | |
Access date | 2014-05-14T14:01:27Z | |
Available date | 2014-05-14T14:01:27Z | |
Document date | 1991 | |
Citation | POMPEU, M. L. et al. Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach. Acta Tropica, v. 48, n. 3, p. 185-193, 1991. | pt_BR |
ISSN | 0001-706X | |
URI | https://www.arca.fiocruz.br/handle/icict/7621 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Granulocytes in the inflammatory process of BALB/c mice infected by Leishmania amazonensis. A quantitative approach. | pt_BR |
Type | Article | pt_BR |
Abstract | We used previously immunized (partially resistant) and naive (highly susceptible) BALB/c mice infected
with Leishrnania amazonensis for evaluating the role of granulocytes in the course of murine leishmaniasis.
The animals were examined at different times post-infection and granulocytes counted in lesion tissues
examined ultra-structurally. Polymorphonuclear granulocytes predominated during the early phase of
infection and their number decreased with progression of infection; their number was similar in both
groups during the early and intermediate phases of infection, though slightly higher in immunized animals
during the late phase. Eosinophils represented approximately 10% of cells in the inflammatory infiltrate,
being higher during the intermediate phase, and not differing between the groups. Another approach was
the evaluation of granulocyte migration to the peritoneal cavity of susceptible BALB/c mice or resistant
C57BL/6 mice under several stimuli. There was no statistically significant difference between resistant and
susceptible animals in any of the treatments. Despite the influx of granulocytes to the lesion and its
possible role in the initial destruction of injected Leishmania, this aspect does not seem to have an
important effect on the outcome of the leishmanial infection. | pt_BR |
Affilliation | Universidade Federal do Ceará. Departamentos de Patologia. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Leishmania amazonensis | pt_BR |
Subject | Granulocytes | pt_BR |
Subject | Neutrophils | pt_BR |
Subject | Eosinophils | pt_BR |
DeCS | Granulócitos/fisiologia | pt_BR |
DeCS | Leishmaniose/patologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Movimento Celular | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Eosinófilos/imunologia | pt_BR |
DeCS | Granulócitos/imunologia | pt_BR |
DeCS | Leishmania/imunologia | pt_BR |
DeCS | Leishmaniose/imunologia | pt_BR |
DeCS | Contagem de Leucócitos | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Neutrófilos/imunologia | pt_BR |
DeCS | Cavidade Peritoneal/patologia | pt_BR |
DeCS | Fagocitose | pt_BR |