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ASSOCIATION OF HEPATOSPLENIC SCHISTOSOMIASIS WITH HLA-DQB1*0201
Hepatopatias Parasitárias/imunologia
Esquistossomose mansoni/imunologia
Esplenopatias/imunologia
Adolescente
Adulto
Alelos
Criança
Pré-Escolar
Cadeias beta de HLA-DQ
Humanos
Lactente
Ativação Linfocitária
Author
Affilliation
Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts
Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Harvard School of Public Health. Department of Tropical Public Health. Boston, Massachusetts
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Hospital Roberto Santos. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Department of Medical Zoology. Saitama Medical School. Saitama, Japan
Abstract
Major histocompatibility class II alleles of 351 persons living in an area endemic for Schistosoma
mansoni in northeastern Brazil were characterized at three loci (DRBl, DQAl, and DQBl). Contingency
analyses were used to compare allele frequencies witfihigh egg excretion, proliferative response
to schistosome soluble egg antigens (SEA), and occurrence of severe, biopsy-confirmed hepatosplenic
disease. There were no associations of HLA-DR or DQ with egg excretion. Patients positive for
DRBl*Ol, DQAl*0101, or DQBl*0501 were less likely to respond to SEA than was the overall
study population. However, using stringent Bonferroni correction (multiplying P values by the
number of alleles tested; P X 35), none of these associations with SEA responsiveness remained
significant. Hepatosplenic disease was less likely in patients positive for DRBI*11 and was more
likely in patients positive for DRBl*07 or DQBl*0201. However, only the DQBl*0201 association
remained significant (odds ratio = 3.72; P < .005) following Bonferroni correction.
DeCS
Antígenos HLA-DQ/genéticaHepatopatias Parasitárias/imunologia
Esquistossomose mansoni/imunologia
Esplenopatias/imunologia
Adolescente
Adulto
Alelos
Criança
Pré-Escolar
Cadeias beta de HLA-DQ
Humanos
Lactente
Ativação Linfocitária
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