Author | Silva, Luciano Kalabric | |
Author | Paraná, Raymundo | |
Author | Souza, Sérgio P. | |
Author | Kay, Alan | |
Author | Trépo, Christian | |
Author | Berby, Françoise | |
Author | Santana, Nelma Pereira de | |
Author | Cotrim, Helma Pinchemel | |
Author | Lyra, Luiz Guilherme Costa | |
Author | Reis, Mitermayer Galvão dos | |
Access date | 2014-05-02T17:51:10Z | |
Available date | 2014-05-02T17:51:10Z | |
Document date | 2000 | |
Citation | SILVA, L. K. et al. Hepatitis C virus genotypes in a northeastern area of Brazil. American Journal of Tropical Medicine and Hygiene, v. 62, n. 2, p. 257-260, 2000. | pt_BR |
ISSN | 0002-9637 | |
URI | https://www.arca.fiocruz.br/handle/icict/7571 | |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | pt_BR |
Title | Hepatitis C virus genotypes in a northeastern area of Brazil. | pt_BR |
Type | Article | pt_BR |
Abstract | We used a reverse transcription-polymerase chain reaction (RT-PCR) to obtain the genotypes of circulating hepatitis C virus (HCV) in patients from a Gastro-Hepatology Unit in the city of Salvador (Bahia State) in northeastern Brazil. Viral RNA was detected in 83 (65.4%) of 127 anti-HCV seropositive serum samples. Positivity was significantly associated with alterations in levels of aspartate aminotransferase and alanine aminotransferase (P < 0.05). Genotyping of HCV was performed by RT-PCR using genotype-specific primers from the core region: 24.1% were infected with subtype 1a, 38.6% with 1b, 3.6% with 2, 21.7% with 3a, and 12.0% with a mixed genotype. There was no difference in genotype distribution when compared with results from other Brazilian locations. Surprisingly, the high frequency of genotype 3 in Brazilian samples continues to be different from that reported around the world and warrants further investigation | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Institut National de la Santé et de la Recherche Médicale Unité. Lyon, France | pt_BR |
Affilliation | Institut National de la Santé et de la Recherche Médicale Unité. Lyon, France | pt_BR |
Affilliation | Institut National de la Santé et de la Recherche Médicale Unité. Lyon, France | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Universitário Professor Edgard Santos. ,Laboratório Gastroenterologia e Hepatologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Hepacivirus/genética | pt_BR |
DeCS | Hepatite C/virologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Alanina Transaminase/sangue | pt_BR |
DeCS | Aspartato Aminotransferases/sangue | pt_BR |
DeCS | Southern Blotting | pt_BR |
DeCS | Brasil/epidemiologia | pt_BR |
DeCS | Primers do DNA/química | pt_BR |
DeCS | DNA Viral/química | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Hepacivirus/química | pt_BR |
DeCS | Hepatite C/epidemiologia | pt_BR |
DeCS | Técnicas Imunoenzimáticas | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | RNA Viral/química | pt_BR |
DeCS | Reação em Cadeia da Polimerase Via Transcriptase Reversa | pt_BR |
DeCS | Estudos Soroepidemiológicos | pt_BR |