Author | Blanton, Ronald Edward | |
Author | Salam, Ekram Abdel | |
Author | Kariuki, H. Curtis | |
Author | Magak, Philip | |
Author | Silva, Luciano Kalabric | |
Author | Muchiri, Eric M. | |
Author | Thiongo, Fredrick | |
Author | Meghid, Iman E.Abdel | |
Author | Butterworth, Anthony E | |
Author | Reis, Mitermayer Galvão dos | |
Author | Ouma, John H. | |
Access date | 2014-04-30T17:46:05Z | |
Available date | 2014-04-30T17:46:05Z | |
Document date | 2002 | |
Citation | BLANTON R. E. et al. Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease. Journal of Infectious Disease, v. 185, n. 11, p. 1644-1649, 2002. | pt_BR |
ISSN | 0022-1899 | |
URI | https://www.arca.fiocruz.br/handle/icict/7562 | |
Language | eng | pt_BR |
Publisher | Infectious Diseases Society of America | pt_BR |
Rights | open access | pt_BR |
Title | Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease. | pt_BR |
Type | Article | pt_BR |
Abstract | Two populations with differing histories of Schistosoma mansoni and hepatitis C infection were compared directly for severity of disease and extent of comorbidity. Demographic, parasitologic, and ultrasound surveys were conducted on 2038 Egyptians and on 2120 Kenyans. Hepatitis B and C serologies and transaminase levels were obtained from a subset at each site. Despite significantly lower prevalence and intensity of infection, Egyptians had a higher prevalence of severe schistosomal fibrosis than Kenyans (36.8% vs. 4.6%). Hepatitis C infection was 3 times more prevalent among Egyptians, and evidence of hepatocellular damage was significantly greater among Egyptians. There was no interaction between S. mansoni infection or disease and the prevalence or severity of hepatitis C. For both infections, the intensity or prevalence of infection was a poor predictor of morbidity. The prevalence of disease in the Egyptian population from different pathogens suggests a generalized susceptibility to inflammatory liver disease. | pt_BR |
Affilliation | Division of Geographic Medicine. Case Western Reserve University. Cleveland, Ohio | pt_BR |
Affilliation | University of Cairo. Department of Pediatrics. Cairo, Egypt | pt_BR |
Affilliation | Division of Vector Borne Diseases. Nairobi | pt_BR |
Affilliation | Office of Radiologic Services. Kenya Ministry of Health. Nairobi, Kenya | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Division of Vector Borne Diseases. Nairobi | pt_BR |
Affilliation | Division of Vector Borne Diseases. Nairobi | pt_BR |
Affilliation | University of Cairo. Department of Pediatrics. Cairo, Egypt | pt_BR |
Affilliation | Biomedical Research and Training Institute. Harare, Zimbabwe | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Division of Vector Borne Diseases. Nairobi | pt_BR |
DeCS | Hepatite C/epidemiologia | pt_BR |
DeCS | Vigilância da População | pt_BR |
DeCS | Esquistossomose mansoni/epidemiologia | pt_BR |
DeCS | Índice de Gravidade de Doença | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Comorbidade | pt_BR |
DeCS | Egito/epidemiologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Hepacivirus/patogenicidade | pt_BR |
DeCS | Hepatite C/ultrassonografia | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Quênia/epidemiologia | pt_BR |
DeCS | Fígado/ultrassonografia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Schistosoma mansoni/patogenicidade | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Esquistossomose mansoni/ultrassonografia | pt_BR |