Author | Reis, Eliana Almeida Gomes | |
Author | Reis, Mitermayer Galvão dos | |
Author | Silva, Rita de Cássia Ribeiro | |
Author | Carmo, Theomira Mauadie de Azevedo | |
Author | Oliveira, Ana Marlucia de | |
Author | Barreto, Maurício Lima | |
Author | Parraga, Isabel Martin | |
Author | Santana, Mônica Leila Portela de | |
Author | Blanton, Ronald Edward | |
Access date | 2014-04-29T14:06:00Z | |
Available date | 2014-04-29T14:06:00Z | |
Document date | 2006 | |
Citation | REIS, E. A. et al. Biochemical and immunologic predictors of efficacy of treatment or reinfection risk for Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene, v. 75, n. 5, p. 904-909, 2006. | pt_BR |
ISSN | 0002-9637 | |
URI | https://www.arca.fiocruz.br/handle/icict/7553 | |
Language | eng | pt_BR |
Publisher | The American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | pt_BR |
Title | Biochemical and immunologic predictors of efficacy of treatment or reinfection risk for Schistosoma mansoni. | pt_BR |
Type | Article | pt_BR |
Abstract | Most Schistosoma mansoni infections are egg-negative after a single dose of oxamniquine. A cohort of 661
infected children was treated at 6-month intervals and assessed for nutritional and parasitological status. Initial biochemical
and immunologic markers were measured in a subset of 84 children. All were treated at the start of therapy
and at 6 months. Immunoglobulins only served as markers for active infection. No markers were predictive of cure or
reinfection, except initial infection intensity and serum low-density lipoprotein. Ten percent were persistently infected
and had no change in infection intensity at any time-point. Several factors suggest that this group was biologically
different. In addition to failing to reduce their worm burden, they had significantly higher initial intensity of infection
(100 versus 65 eggs/g, P 0.001) and significantly lower initial serum low-density lipoprotein (72 versus 104 mg/dL,
P 0.045). The biologic plausibility of this observation is discussed. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Nutrition. Salvador, BA, BRasil | pt_BR |
Affilliation | Institute of Collective Health. Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Department of Nutrition. Case Western Reserve University. Cleveland, Ohio | pt_BR |
Affilliation | School of Nutrition. Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Center for Global Health and Diseases. Case Western Reserve University. Cornell Road. Building, Cleveland, Ohio | pt_BR |
DeCS | Valor Preditivo dos Testes | pt_BR |
DeCS | Recidiva | pt_BR |
DeCS | Schistosoma mansoni/imunologia | pt_BR |
DeCS | Esquistossomose mansoni/fisiopatologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Estudos de Coortes | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Esquistossomose mansoni/quimioterapia | pt_BR |
DeCS | Esquistossomose mansoni/epidemiologia | pt_BR |
DeCS | Resultado do Tratamento | pt_BR |