Author | Machado Junior, Almério | |
Author | Finkmoore, Brook | |
Author | Emodi, Krisztina | |
Author | Takenami, Iukary Oliveira | |
Author | Bessa, Theolis Costa Barbosa | |
Author | Tavares, Maria Brandão | |
Author | Reis, Mitermayer Galvão dos | |
Author | Arruda, Sérgio Marcos | |
Author | Riley, Lee Woodland | |
Access date | 2014-04-14T17:35:21Z | |
Available date | 2014-04-14T17:35:21Z | |
Document date | 2009 | |
Citation | MACHADO JUNIOR, A. et al. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.The International Journal of Tuberculosis and Lung Disease, v. 13, n. 6, p. 719-725, 2009. | pt_BR |
ISSN | 1027-3719 | |
URI | https://www.arca.fiocruz.br/handle/icict/7518 | |
Language | eng | pt_BR |
Publisher | The Union | pt_BR |
Rights | open access | pt_BR |
Title | Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil. | pt_BR |
Type | Article | pt_BR |
Abstract | BACKGROUND: Although treatment of latent tuberculosis infection (LTBI) is an essential component of tuberculosis (TB) control in countries such as the United States, it is not widely practiced in most TB-endemic countries. OBJECTIVE: To examine the practice of and adherence to LTBI treatment in a high-risk population in Brazil. DESIGN: We followed household contacts (HHCs) of patients hospitalized with pulmonary TB in Salvador, Brazil, for 6 months after they initiated LTBI treatment with isoniazid (INH). HHCs were asked to return to the hospital once a month for 6 months for follow-up visits and INH refills. RESULTS: Of 101 HHCs who initiated LTBI treatment, 54 (53.5%) completed the 6-month regimen. The risk of treatment non-completion was significantly higher in HHCs who reported side effects to INH (RR 2.69, 95%CI 1.3-5.8, P = 0.01), and in those who had to take two buses for a one-way trip to the hospital (RR 1.8, 95%CI 1.01-3.3, P = 0.04). Of the 101 HHCs, 29 (28.7%) did not return for any follow-up visits; these HHCs were significantly more likely to have a 2-bus commute to the hospital compared to HHCs who completed treatment (OR 20.69, 95%CI 2.1-208.4, P = 0.01). CONCLUSION: Nearly 50% of HHCs at high risk for developing TB completed a 6-month course of LTBI treatment. Completion of LTBI treatment was most affected by medication intolerance and commuting difficulties for follow-up visits. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Especializado Octávio Mangabeira. Salvador, BA, Brasil | pt_BR |
Affilliation | University of California. Berkeley School of Public Health. California, USA | pt_BR |
Affilliation | University of California. Berkeley School of Public Health. California, USA | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz, Salvador, BA, BraSil | pt_BR |
Affilliation | University of California. Berkeley School of Public Health. California, USA | pt_BR |
Subject | Latent tuberculosis infection | pt_BR |
Subject | Isoniazid | pt_BR |
Subject | Adherence | pt_BR |
Subject | hoUsehold contacts | pt_BR |
DeCS | Antituberculosos/uso terapêutico | pt_BR |
DeCS | Isoniazida/uso terapêutico | pt_BR |
DeCS | Adesão à Medicação | pt_BR |
DeCS | Tuberculose Pulmonar/quimioterapia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Pré-Escolar | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Seguimentos | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Lactente | pt_BR |
DeCS | Recém-Nascido | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Estudos Prospectivos | pt_BR |
DeCS | Fatores de Risco | pt_BR |
DeCS | Transportes | pt_BR |
DeCS | Adulto Jovem | pt_BR |