Author | Ferreira, Gabriella Freitas | |
Author | Moraes, Cícero | |
Author | Silveira, Alda Maria Soares da | |
Author | Oliveira, Rodrigo Corrêa de | |
Author | Carvalho, Andréa Teixeira de | |
Author | Martins Filho, Olindo Assis | |
Author | Moreno, Elizabeth Castro | |
Author | Carmo, Luiz Simeão do | |
Author | Fraga, Lucia Alves de Oliveira | |
Author | Malaquias, Luiz Cosme Cotta | |
Access date | 2014-03-21T12:42:24Z | |
Available date | 2014-03-21T12:42:24Z | |
Document date | 2012 | |
Citation | FERREIRA, Freitas Ferreira et al. Distinct cytokine profiles of circulating mononuclear cells stimulated with Staphylococcus aureus enterotoxin A in vitro during early and late episodes of chronic osteomyelitis. Memórias do Instituto Oswaldo Cruz. 2012, vol.107, n.3, pp. 348-355. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/7432 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | Distinct cytokine profiles of circulating mononuclear cells stimulated with Staphylococcus aureus enterotoxin A in vitro during early and late episodes of chronic osteomyelitis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762012000300009 | |
Abstract | We investigated the cytokine profile of peripheral mononuclear cells from chronic osteomyelitis (OST) patients following in vitro stimulation with staphylococcal enterotoxin A (SEA). We demonstrate that stimulation with SEA induced prominent lymphocyte proliferation and high levels of tumour necrosis factor (TNF)-α, interleukin (IL)-4 and IL-10 secretion in both OST and non-infected individuals (NI). Even though stimulation with SEA had no impact on IL-6 production in either patient group, the baseline level of IL-6 production by cells from OST patients was always significantly less than that produced by cells from NI. After classifying the osteomyelitic episodes based on the time after the last reactivation event as "early" (1-4 months) or "late" osteomyelitis (5-12 months), we found that increased levels of TNF-α and IL-4 in combination with decreased levels of IL-6 were observed in the early episodes. By contrast, increased levels of IL-10, IL-2 and IL-6 were hallmarks of late episodes. Our data demonstrate that early osteomyelitic episodes are accompanied by an increased frequency of "high producers" of TNF-α and IL-4, whereas late events are characterised by increased frequencies of "high producers" of IL-10, IL-6 and IL-2. These findings demonstrate the distinct cytokine profiles in chronic osteomyelitis, with a distinct regulation of IL-6 production during early and late episodes. | pt_BR |
Affilliation | Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil/Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Programa de Pós-Graduação em Ciências Biológicas. Governador Valadares, MG, Brasil | pt_BR |
Affilliation | Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil/Hospital Municipal. Governador Valadares, MG, Brasil | pt_BR |
Affilliation | Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil/Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Programa de Pós-Graduação em Ciências Biológicas. Governador Valadares, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Hemominas. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia e Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil/Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Programa de Pós-Graduação em Ciências Biológicas. Governador Valadares, MG, Brasil | pt_BR |
Affilliation | Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil/ Universidade Vale do Rio Doce. Núcleo de Pesquisa em Imunologia. Programa de Pós-Graduação em Ciências Biológicas. Governador Valadares, MG, Brasil/Universidade Federal de Alfenas. Departamento de Ciências Biomédicas. Laboratório de Microbiologia e Imunologia Básica. Alfenas, MG, Brasil | pt_BR |
Subject | Staphylococcus aureus | pt_BR |
Subject | enterotoxin A | pt_BR |
Subject | chronic osteomyelitis | pt_BR |
Subject | cytokines | pt_BR |
Subject | IL-6 | pt_BR |