Author | Cota, Betania Barros | |
Author | Siqueira Filho, Ezequias Pessoa de | |
Author | Oliveira, Djalma Menezes de | |
Author | Alves, Tânia Maria de Almeida | |
Author | Sobral, Marcos Eduardo Guerra | |
Author | Rabello, Ana Lúcia Teles | |
Author | Zani, Carlos Leomar | |
Access date | 2014-03-19T16:33:19Z | |
Available date | 2014-03-19T16:33:19Z | |
Document date | 2012 | |
Citation | COTA, Betania Barros et al. Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis. Revista Brasileira de Farmacognosia. 2012, vol.22, n.6, pp. 1253-1258. | pt_BR |
ISSN | 0102-695X | |
URI | https://www.arca.fiocruz.br/handle/icict/7422 | |
Language | eng | pt_BR |
Publisher | Sociedade Brasileira de Farmacognosia | pt_BR |
Rights | open access | pt_BR |
Title | Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0102-695X2012005000095 | |
Abstract | Many phenolic compounds such as xanthones, quinones and coumarins have been isolated from Kielmeyera species; however the presence of flavonoids have been showed in other genera in the Calophylleae tribe as Caraipa, Mesua and Calophyllum. Six known glycosidic flavonoids: quercetin 3-β-O-galactopyranoside (1), quercetin 3-β-O-glucopyranoside (2), quercetin 3-O-α-rhamnoside (3), luteolin 6-C-β-glucopyranoside (4), isovitexin (5), kaempferol 3-O-α-rhamnoside (6) and one triterpene, lupenone (7) were isolated, for the first time, from organic crude extract of Kielmeyera variabilis Mart. & Zucc., Calophyllaceae, leaves. The crude organic extract from K. variabilis leaves exhibited 95% of leishmanidal activity at 20 µg/mL on amastigote-like form of Leishmania (Leishmania) amazonensis in vitro model and only compound 3 showed 40-45% of growth inhibition at concentration ranging from 0.78 to 20 µg/mL. In addition, quercetin 3-O-α-rhamnoside (quercitrin) was found to be the major metabolite. Our results and previous reports suggest that synergistic effects of flavonoid glycosides are the cause of significant leishmanidal activity of the crude organic extract from K. variabilis leaves. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Estadual do Sudoeste da Bahia. Departamento de Química e Exatas. Jequié, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de São João Del-Rei. Departamento de Ciências Naturais. São João Del-Rei, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil | pt_BR |
Subject | Kielmeyera variabilis | pt_BR |
Subject | phenolic compounds | pt_BR |
Subject | C-flavonoid | pt_BR |
Subject | glycosides | pt_BR |
Subject | lupenone | pt_BR |
Subject | leishmanicidal activity | pt_BR |