Author | Andrade, Bruno de Bezerril | |
Author | Oliveira, Camila Indiani de | |
Author | Brodskyn, Claudia Ida | |
Author | Barral, Aldina Maria Prado | |
Author | Barral Netto, Manoel | |
Access date | 2014-03-17T16:41:36Z | |
Available date | 2014-03-17T16:41:36Z | |
Document date | 2007 | |
Citation | ANDRADE, B. B. et al. Role of sand fly saliva in human and experimental leishmaniasis: current insights. Scandinavian Journal of Immunology, v. 66, n. 2-3, p. 122–127, 2007. | pt_BR |
ISSN | 0300-9475 | |
URI | https://www.arca.fiocruz.br/handle/icict/7410 | |
Language | eng | pt_BR |
Publisher | Blackwell Publishing Ltd | pt_BR |
Rights | open access | pt_BR |
Title | Role of sand fly saliva in human and experimental leishmaniasis: current insights. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1365-3083.2007.01964.x | |
Abstract | Leishmaniases are wide spread diseases transmitted to their vertebrate host by
infected sand fly. The saliva from these arthropods contains a vast repertoire of
pharmacologically active molecules that hampers the host’s haemostatic,
inflammatory and immune responses. The early interactions between Leishmania
and the host’s immune response are closely linked to disease evolution
or protection against the protozoan, and the ectoparasite saliva contributes
directly to these interactions. Current studies have depicted these features, and
these relations are being widely explored. There are concrete indications that
the host response against sand fly saliva influences disease outcome in leishmaniasis.
Additionally, there are demonstrations that immunization with
whole sand fly saliva, or its components, leads to protection against leishmaniasis
in different host species. The combination of these evidences opens up
optimistic perspectives for improving vaccine development against Leishmania
infection. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil | pt_BR |
DeCS | Leishmania/crescimento & desenvolvimento | pt_BR |
DeCS | Leishmania/imunologia | pt_BR |
DeCS | Leishmaniose/imunologia | pt_BR |
DeCS | Leishmaniose/parasitologia | pt_BR |
DeCS | Psychodidae/imunologia | pt_BR |
DeCS | Psychodidae/parasitologia | pt_BR |
DeCS | Saliva/imunologia | pt_BR |
DeCS | Saliva/parasitologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Humanos | pt_BR |