Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/7258
THE IMMUNOBIOLOGY OF LEISHMANIA BRAZILIENSIS INFECTION
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil
Abstract
LeishmaniasesareagroupofdiseasescausedbyprotozoaofthegenusLeishmaniathataffectmillionsofpeopleworldwide.ThesediseasesarecausedbydistinctLeishmaniaspecies,ofwhichL.braziliensis,aNewWorldrepresentativeoftheLeishmaniagenus,hasbeentheleaststudied.AlthoughleishmaniasiscausedbyL.braziliensisinducesarangeofclinicalmanifestationsrangingfrommildlocalizedlesionstoseveremucosalinvolvement,fewstudieshavefocusedonelucidatingtheimmunemechanismsbehindthispathology.Inthisreview,wefocusontheimmunobiologyofL.braziliensisinfection,emphasizingtheinnateandadaptiveimmuneresponsesandtakingintoconsiderationbothstudiesperformedinendemicareasandexperimentalmodelsofinfection.Additionally,weaddressrecentfindingsregardingtheroleofsandflysalivaindiseaseimmunopathogenesisandvaccinedevelopment.
Share